Cochrane · systematic review · CD012738
Implantable cardiac defibrillators for people with non‐ischaemic cardiomyopathy
El Moheb, M, Nicolas, J, Khamis, AM, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
HeartAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
6
No studies
2
Included studies
NR
No studies 2 · 25%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 4 · 50%High 2 · 25%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
ICD plus optimal medical therapy compared to optimal medical therapy alone for people with non‐ischaemic cardiomyopathy
Population: people with non‐ischaemic cardiomyopathy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Outcomes length of ICD plus optimal medical therapy vs optimal medical therapy alone | no estimate extracted | NR | No studies |
All‐cause mortality (HR) ‐ main analysisa 16.5 to 67.6 months ICD plus optimal medical therapy vs optimal medical therapy alone | HR 0.78 [0.66, 0.92] | 6 studies · 3128 participants | High |
Cardiovascular mortality (RR)b 22.8 to 67.6 months ICD plus optimal medical therapy vs optimal medical therapy alone | RR 0.75 [0.46, 1.21] | 4 studies · 1781 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Sudden cardiac death (HR)a 24 to 67.6 months ICD plus optimal medical therapy vs optimal medical therapy alone | HR 0.45 [0.29, 0.7] | 3 studies · 1677 participants | High |
Adverse events 67.7 months ICD plus optimal medical therapy vs optimal medical therapy alone | no estimate extracted | 1 study · 1116 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Noncardiovascular mortality (RR)b 22.8 to 67.6 months ICD plus optimal medical therapy vs optimal medical therapy alone | RR 1.17 [0.81, 1.68] | 4 studies · 1781 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Health‐related quality of life 24 to 29 months ICD plus optimal medical therapy vs optimal medical therapy alone | no estimate extracted | 2 studies · 561 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
First ICD‐related hospitalisation ‐ not reported ICD plus optimal medical therapy vs optimal medical therapy alone | no estimate extracted | NR | No studies |