Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

56 questions · 61 findings · 34 reviews · Heart

No studies found 19 · 31.1%GRADE not reported 2 · 3.3%Very low 5 · 8.2%Low 9 · 14.8%Moderate 21 · 34.4%High 5 · 8.2%

Angiotensin‐converting enzyme inhibitors vs placebo or no treatment

Cardiovascular mortality · patients with chronic heart failure with preserved ejection fraction

Angiotensin‐converting enzyme inhibitors (ACEIs) showed no clear difference in cardiovascular mortality (RR) compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Angiotensin receptor blockers (ARBs) vs placebo or no treatment

Cardiovascular mortality · patients with chronic heart failure with preserved ejection fraction

Angiotensin receptor blockers (ARBs) showed no clear difference in cardiovascular mortality (RR) compared with placebo or no treatment (high certainty).

1 finding from 1 review

Mineralocorticoid receptor antagonists (MRAs) vs placebo or no treatment

Cardiovascular mortality · patients with chronic heart failure with preserved ejection fraction

Mineralocorticoid receptor antagonists (MRAs) showed no clear difference in cardiovascular mortality (RR) compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

clopidogrel plus aspirin vs aspirin

Cardiovascular mortality · people with coronary disease, ischaemic cerebrovascular disease, peripheral arterial disease or at high risk of atherothrombotic disease

clopidogrel plus aspirin showed no clear difference in cardiovascular mortality compared with aspirin alone (moderate certainty).

1 finding from 1 review

Intervention not reported

Cardiovascular mortality ( · people with or at risk of cardiovascular disease

The intervention showed no clear difference in cardiovascular mortality ( (moderate certainty).

1 finding from 1 review

Ranolazine (monotherapy) vs placebo

Cardiovascular mortality · patients with stable angina pectoris

Ranolazine (monotherapy) showed no clear difference in cardiovascular mortality compared with placebo (low certainty).

1 finding from 1 review

Intervention not reported

Total cardiovascular mortality · Free‐living adults who were healthy, had established cardiovascular disease or risk factors for cardiovascular disease

The review found no eligible studies for this question.

1 finding from 1 review