Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

18 questions · 18 findings · 9 reviews · Eyes and Vision

No studies found 3 · 16.7%GRADE not reported 2 · 11.1%Very low 2 · 11.1%Low 3 · 16.7%Moderate 6 · 33.3%High 2 · 11.1%

Combined steroid and antibiotic therapy vs antibiotics alone

Adverse events at 3 to 12 months' · eyes with acute endophthalmitis following an intraocular procedure (e.g. surgery, intravitreous injection)

Combined steroid and antibiotic therapy showed no clear difference in adverse events at 3 to 12 months' compared with antibiotics alone (low certainty).

1 finding from 1 review

Tocilizumab every 4 weeks vs placebo

Adverse events at ≥ 12 months · adults aged over 50 years with giant cell arteritis

Tocilizumab every 4 weeks showed no clear difference in adverse events at ≥ 12 months compared with placebo (moderate certainty).

1 finding from 1 review

Tocilizumab weekly vs placebo + 52‐week taper

Adverse events at ≥ 12 months · adults aged over 50 years with giant cell arteritis

Tocilizumab weekly showed no clear difference in adverse events at ≥ 12 months compared with placebo + 52‐week taper (moderate certainty).

1 finding from 1 review

Tocilizumab weekly vs placebo + 26‐week taper

Adverse events at ≥ 12 months · adults aged over 50 years with giant cell arteritis

Tocilizumab weekly showed no clear difference in adverse events at ≥ 12 months compared with placebo + 26‐week taper (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse events 12 months postintervention · adults with refractory glaucoma

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse events 12 months postintervention · adults with refractory glaucoma
1 finding from 1 review

Blue‐light filtering intraocular lenses (IOL) vs non blue‐light filtering IOL

Proportion of participants with adverse events with a probable causal link with the study interventions at six months · adults undergoing cataract surgery with IOL implantation

The review found no eligible studies for this question.

1 finding from 1 review

Photobiomodulation treatment vs no treatment/sham

Adverse events: AMD progression at 12 months Defined as increased drusen volume or onset of advanced AMD. Conversion to exudative AMD at 12 months Assessed by clinical examination and retinal optical coherence tomography. · people with non‐exudative AMD (AREDS 2 to 4)

Photobiomodulation treatment showed no clear difference in adverse events: AMD progression at 12 months Defined as increased… compared with sham or no treatment (low certainty).

1 finding from 1 review