Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

70 questions · 70 findings · 51 reviews · Pain, Palliative and Supportive Care

No studies found 9 · 12.9%GRADE not reported 3 · 4.3%Very low 42 · 60%Low 8 · 11.4%Moderate 8 · 11.4%High 0 · 0%

Low dose naldemedine vs higher dose

Serious adverse eventsg · people with cancer irrespective of whether receiving palliative care and with opioid‐induced bowel dysfunction

Low dose naldemedine showed no clear difference in serious adverse eventsg compared with higher doses (low certainty).

1 finding from 1 review

Naloxone + oxycodone prolonged release tablets vs oxycodone

Serious adverse eventsg · people with cancer irrespective of whether they were receiving palliative care opioid‐induced bowel dysfunction

It is very uncertain whether naloxone + oxycodone prolonged release tablets changes serious adverse eventsg compared with oxycodone prolonged‐released tablets (very low certainty).

1 finding from 1 review

Naldemedine vs placebo

Serious adverse eventsh · people with cancer irrespective of whether receiving palliative care and with opioid‐induced bowel dysfunction

Naldemedine showed no clear difference in serious adverse eventsh compared with placebo (low certainty).

1 finding from 1 review