Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,918 questions · 5,537 findings · 1,803 reviews

No studies found 1,309 · 23.6%GRADE not reported 440 · 7.9%Very low 1,560 · 28.2%Low 1,292 · 23.3%Moderate 751 · 13.6%High 185 · 3.3%

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Intervention not reported

Serious adverse eventsClinical manifestation and laboratory examination · people with acute herpes zoster (within 7 days of onset of rash)

It is very uncertain whether the intervention changes serious adverse eventsClinical manifestation and laboratory… (very low certainty).

1 finding from 1 review

Glutamate modulators vs placebo

Dropouts due to adverse events · children and adolescents with trichotillomania

Glutamate modulators showed no clear difference in tolerability of treatment ‐ dropouts due to adverse eventscDropout… compared with placebo (low certainty).

1 finding from 1 review

TCAs with predominantly SRI actions vs placebo

Dropouts due to adverse events · adults with trichotillomania

It is very uncertain whether TCAs with predominantly SRI actions changes tolerability of treatment ‐ dropouts due to adverse eventsdDropout… compared with placebo (very low certainty).

1 finding from 1 review

Long‐term red cell transfusion vs hydroxyurea and phlebotomy

Serious adverse events as a result of sickle cell‐related complications · individuals with sickle cell disease who are at risk of a primary stroke who have had long‐term red cell transfusions to prevent a stroke

It is very uncertain whether long‐term red cell transfusion changes serious adverse events as a result of sickle cell‐related… compared with hydroxyurea and phlebotomy (very low certainty).

1 finding from 1 review

Long‐term red cell transfusion vs hydroxyurea and phlebotomy

Serious adverse events as a result of sickle cell‐related complications · individuals with sickle cell disease who have had a stroke who have had long‐term red cell transfusions to prevent another stroke

It is very uncertain whether long‐term red cell transfusion changes serious adverse events as a result of sickle cell‐related… compared with hydroxyurea and phlebotomy (very low certainty).

1 finding from 1 review

Long‐term red cell transfusion vs no transfusion

Serious adverse events as a result of sickle cell‐related complications · individuals with sickle cell disease who are at risk of a primary stroke who have not had previous long‐term red cell transfusions

Long‐term red cell transfusion may leads to lower serious adverse events as a result of sickle cell‐related… compared with no transfusion (low certainty).

1 finding from 1 review

Enteral vs enteral and parenteral nutrition

Adverse events ‐ pneumonia · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes participants with acute…

It is very uncertain whether enteral changes adverse events: pneumonia (as reported by study authors at end of… compared with enteral and parenteral nutrition (very low certainty).

1 finding from 1 review

Enteral vs parenteral nutrition

Adverse events ‐ pneumonia · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes participants with acute…

Enteral showed no clear difference in adverse events: pneumonia (as reported by study authors at end of… compared with parenteral nutrition (low certainty).

1 finding from 1 review

Neonatal vitamin A supplementation vs control

Vomiting · mortality and morbidity in term neonates

Neonatal vitamin A supplementation showed no clear difference in adverse events during first 48‐72 hours post supplementation ‐… compared with control (high certainty).

1 finding from 1 review

Laparoscopic myomectomy vs open myomectomy (all types)

Perioperative in‐hospital adverse events; unscheduled return to theatre · women with uterine fibroids

Laparoscopic myomectomy showed no clear difference in perioperative in‐hospital adverse events; unscheduled return to… compared with open myomectomy (all types) (low certainty).

1 finding from 1 review

Recombinant zoster vaccine vs placebo

Adverse effects of any severity (systemic symptoms) · healthy older adults aged ≥ 60 years

Recombinant zoster vaccine probably leads to higher participants with adverse events ‐ any systemic symptomClinical… compared with placebo (moderate certainty).

1 finding from 1 review

Diclofenac vs paracetamol

Serious adverse events during the study period · children with acute postoperative pain

It is very uncertain whether diclofenac changes serious adverse events during study period № of participants: 60 (1… compared with paracetamol (very low certainty).

1 finding from 1 review