Cochrane · systematic review · CD002010
Bisphosphonates for osteoporosis in people with cystic fibrosis
Jeffery, TC, Chang, AB, Conwell, LS · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
Cystic Fibrosis and Genetic DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
18
current version
GRADE rated
10
No studies
3
Included studies
NR
No studies 3 · 16.7%Ungraded 5 · 27.8%Very low 2 · 11.1%Low 7 · 38.9%Moderate 1 · 5.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Bisphosphonates compared with control for osteoporosis in people with cystic fibrosis who have not had a lung transplant
Population: adults with cystic fibrosis who have not had a lung transplant
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
New vertebral fractures Bisphosphonates vs control | no estimate extracted | 5 studies · 142 participants | Very low Downgraded: risk of bias, imprecision |
New non‐vertebral fractures Bisphosphonates vs control | no estimate extracted | 4 studies · 95 participants | Very low Downgraded: risk of bias, imprecision |
BMD: % change in BMD at the lumbar spine Bisphosphonates vs control | no estimate extracted | 6 studies · 171 participants | Low Downgraded: risk of bias |
BMD: % change in BMD at the hip or femur Bisphosphonates vs control | no estimate extracted | 5 studies · 155 participants | Low Downgraded: risk of bias |
QoL: change in physical and mental component scores (SF36v2) Bisphosphonates vs control | no estimate extracted | 1 study · 47 participants | Low Downgraded: imprecision, inconsistency |
Adverse events: bone pain (all routes of bisphosphonate administration) Bisphosphonates vs control | no estimate extracted | 7 studies · 206 participants | Moderate Downgraded: risk of bias |
Bisphosphonates compared with placebo for osteoporosis in children with cystic fibrosis who have not had a lung transplant
Population: children with cystic fibrosis who have not had a lung transplant
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
New vertebral fractures Bisphosphonates vs placebo | OR 0.32 [0.03, 3.13] | 1 study · 113 participants | Low Downgraded: imprecision |
New non‐vertebral fractures Bisphosphonates vs placebo | OR 0.19 [0.01, 4.04] | 1 study · 113 participants | Low Downgraded: imprecision |
BMD: % change in BMD at the lumbar spine Bisphosphonates vs placebo | no estimate extracted | 1 study · 113 participants | Low Downgraded: imprecision |
BMD: % change in BMD at the hip or femur Bisphosphonates vs placebo | no estimate extracted | NR | No studies |
QoL Bisphosphonates vs placebo | no estimate extracted | NR | No studies |
Adverse events Bisphosphonates vs placebo | no estimate extracted | 1 study · 113 participants | Low Downgraded: imprecision |
Bisphosphonates compared with no bisphosphonates for osteoporosis in people with cystic fibrosis who have had a lung transplant
Population: adults with cystic fibrosis who have had a lung transplant
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
New vertebral fractures Bisphosphonates vs no bisphosphonates | no estimate extracted | 12 participants | Ungraded |
New non‐vertebral fractures Bisphosphonates vs no bisphosphonates | no estimate extracted | 12 participants | Ungraded |
BMD: % change in BMD at the lumbar spine Bisphosphonates vs no bisphosphonates | no estimate extracted | 12 participants | Ungraded |
BMD: % change in BMD at the hip or femur Bisphosphonates vs no bisphosphonates | no estimate extracted | 12 participants | Ungraded |
QoL Bisphosphonates vs no bisphosphonates | no estimate extracted | NR | No studies |
Adverse events Bisphosphonates vs no bisphosphonates | no estimate extracted | 12 participants | Ungraded |