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Evidence found and GRADE certainty

4,918 questions · 5,537 findings · 1,803 reviews

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No studies found 1,309 · 23.6%GRADE not reported 440 · 7.9%Very low 1,560 · 28.2%Low 1,292 · 23.3%Moderate 751 · 13.6%High 185 · 3.3%

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Cannabinoids vs placebo

Adverse events: psychological disorders · diagnosis of dementia (dementia in Alzheimer’s disease, vascular dementia, or mixed dementia; any severity

Comparison: cannabinoids showed no clear difference in adverse events ‐ psychiatric disorders ‐ total psychiatric disorders ( compared with placebo (low certainty).

1 finding from 1 review

Vitamin D plus calcium vs calcium

Adverse events (number) Asymptomatic hypercalcaemia and hypercalciuria

It is very uncertain whether vitamin D plus calcium changes adverse events (number) Asymptomatic hypercalcaemia and hypercalciuria compared with calcium (very low certainty).

1 finding from 1 review

Omega‐3 vs placebo

Adverse effects: neurological, extrapyramidal UKU (events) Medium‐term · people in the prodromal stage of psychosis

Group A: omega‐3 fatty acids showed no clear difference in adverse effects: neurological, extrapyramidal UKU (events) Medium‐term compared with placebo (low certainty).

1 finding from 1 review

Hysterectomy with opportunistic salpingectomy vs hysterectomy without opportunistic salpingectomy

Surgery‐related adverse events: short‐term postoperative complications · premenopausal women undergoing hysterectomy for benign gynaecological indications

It is very uncertain whether hysterectomy with opportunistic salpingectomy changes surgery‐related adverse events: short‐term postoperative complications compared with hysterectomy without opportunistic salpingectomy (very low certainty).

1 finding from 1 review

Enteral vs enteral and parenteral nutrition

Adverse events: Vomiting · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes participants with acute…

The review found no eligible studies for this question.

1 finding from 1 review

Enteral vs parenteral nutrition

Adverse events: Vomiting · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes participants with acute…

It is very uncertain whether enteral changes adverse events: vomiting (as reported by study authors at end of study compared with parenteral nutrition (very low certainty).

1 finding from 1 review

Active cancer therapy combined with TCM vs active cancer therapy

Adverse events ‐ renal and hepatic impairment ‐ Fuzheng Guben granules · patients with oesophageal cancer

Active cancer therapy combined with TCM may leads to lower adverse events ‐ renal and hepatic impairment ‐ Fuzheng Guben granules compared with active cancer therapy (low certainty).

1 finding from 1 review

Protease‐modulating matrix dressing regimen vs any other dressing regimen

Proportion of participants with 1 or more adverse events at 2‐12 weeks · people with venous leg ulcers

Protease‐modulating matrix dressing regimen showed no clear difference in proportion of participants with 1 or more adverse events at 2‐12 weeks compared with any other dressing regimen (low certainty).

1 finding from 1 review

PERPHENAZINE vs placebo

Adverse events: extrapyramidal adverse effects ‐ dystonia ‐ short term · patients with schizophrenia

It is very uncertain whether PERPHENAZINE changes adverse events: extrapyramidal adverse effects ‐ dystonia ‐ short term compared with PLACEBO (very low certainty).

1 finding from 1 review