Cochrane · systematic review · CD011918
Protease‐modulating matrix treatments for healing venous leg ulcers
Westby, MJ, Norman, G, Dumville, JC, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
WoundsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 20%Low 4 · 80%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Protease‐modulating matrix dressing regimen compared to any other dressing regimen for healing venous leg ulcers
Population: people with venous leg ulcers
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
TIme to complete healing Protease‐modulating matrix dressing regimen vs any other dressing regimen | HR 1.21 [0.74, 1.97] | 1 study · 100 participants | Low Downgraded: imprecision |
Proportion of participants healed ‐ short term (4‐8 weeks) Protease‐modulating matrix dressing regimen vs any other dressing regimen | RR 0.73 [0.34, 1.58] | 2 studies · 207 participants | Very low Downgraded: risk of bias, imprecision |
Proportion of participants healed ‐ medium term (12 weeks) Protease‐modulating matrix dressing regimen vs any other dressing regimen | RR 1.28 [0.95, 1.71] | 4 studies · 192 participants | Low Downgraded: risk of bias, imprecision |
Proportion of participants healed ‐ long term (over 24 weeks) Protease‐modulating matrix dressing regimen vs any other dressing regimen | RR 1.06 [0.8, 1.41] | 1 study · 100 participants | Low Downgraded: risk of bias, imprecision |
Proportion of participants with 1 or more adverse events at 2‐12 weeks Protease‐modulating matrix dressing regimen vs any other dressing regimen | RR 1.03 [0.75, 1.42] | 5 studies · 363 participants | Low Downgraded: risk of bias, imprecision |