Findings

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Evidence found and GRADE certainty

4,918 questions · 5,537 findings · 1,803 reviews

No studies found 1,309 · 23.6%GRADE not reported 440 · 7.9%Very low 1,560 · 28.2%Low 1,292 · 23.3%Moderate 751 · 13.6%High 185 · 3.3%

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Trapeziectomy with ligament reconstruction and tendon interposition (T and LRTI) vs trapeziectomy and interpositional arthroplasty (T and IA)

Adverse events Complications reported · Patients with thumb (trapeziometacarpal joint) osteoarthritis

Trapeziectomy with ligament reconstruction and tendon interposition… showed no clear difference in adverse events complications reported compared with trapeziectomy and interpositional arthroplasty (T and IA) (moderate certainty).

1 finding from 1 review

Trapeziectomy with interpositional arthroplasty (T and IA) vs trapeziometacarpal joint replacement (Swanson)

Adverse events Complications reported · Patients with thumb (trapeziometacarpal joint) osteoarthritis

Trapeziectomy with interpositional arthroplasty (T and IA) showed no clear difference in adverse events Complications reported compared with trapeziometacarpal joint replacement (Swanson) (low certainty).

1 finding from 1 review

Trapeziectomy with interpositional arthroplasty (T and IA) vs trapeziectomy (T)

Adverse events Complications reported · Patients with thumb (trapeziometacarpal joint) osteoarthritis

Trapeziectomy with interpositional arthroplasty (T and IA) showed no clear difference in adverse events Complications reported compared with trapeziectomy (T) (moderate certainty).

1 finding from 1 review

Trapeziectomy with ligament reconstruction and tendon interposition (T and LRTI) vs trapeziectomy (T)

Adverse events Complications reported · Patients with thumb (trapeziometacarpal joint) osteoarthritis

Trapeziectomy with ligament reconstruction and tendon interposition… showed no clear difference in adverse events Complications reported compared with trapeziectomy (T) (low certainty).

1 finding from 1 review

Indacaterol vs long‐acting beta2‐agonist alone

Serious adverse events Adverse events · patients with chronic obstructive pulmonary disease

Indacaterol showed no clear difference in serious adverse events Adverse events compared with twice‐daily long‐acting beta2‐agonists (moderate certainty).

1 finding from 1 review

Intervention not reported

Discontinuation due to adverse events · Patients with fibromyalgia

It is very uncertain whether the intervention changes discontinuation due to adverse events (very low certainty).

1 finding from 1 review

Methotrexate vs placebo

Serious adverse events(up to 6 months) · children and young people with JIA

Methotrexate showed no clear difference in serious adverse events(up to 6 months) compared with placebo (low certainty).

1 finding from 1 review

Remdesivir and standard care vs placebo or usual care

Serious adverse events at up to day 28 · hospitalised individuals with COVID‐19 (moderate to severe disease)

Remdesivir and standard care showed no clear difference in serious adverse events at up to day 28 compared with standard care (plus/minus placebo) (low certainty).

1 finding from 1 review

Timing of wound closure (immediate vs delayed)

Adverse events ‐ superficial infection · adults with open long bone fractures of the upper and lower limbs

It is very uncertain whether timing of wound closure (immediate changes adverse events ‐ superficial infection compared with delayed) (very low certainty).

1 finding from 1 review

Casirivimab/imdevimab vs placebo

Serious adverse events within 6 months · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

It is very uncertain whether casirivimab/imdevimab changes serious adverse events within 6 months compared with placebo (very low certainty).

1 finding from 1 review

Hydromorphone vs fentanyl

Constipation · people with moderate to severe cancer pain

The review found no eligible studies for this question.

1 finding from 1 review

Hydromorphone vs oxycodone

Constipation · people with moderate to severe cancer pain

It is very uncertain whether hydromorphone changes specific adverse events – constipation compared with oxycodone (very low certainty).

1 finding from 1 review