Cochrane · systematic review · CD012799
Selective serotonin re‐uptake inhibitors for premature ejaculation in adult men
Sathianathen, NJ, Hwang, EC, Mian, R, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
UrologyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 28.6%Moderate 5 · 71.4%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
SSRI compared to placebo for premature ejaculation
Population: adult men with premature ejaculation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Participant perception of change with treatment SSRI vs placebo | RR 1.92 [1.66, 2.23] | 6 studies · 3260 participants | Moderate Downgraded: risk of bias |
Participant satisfaction with intercourse SSRI vs placebo | RR 1.63 [1.42, 1.87] | 3 studies · 4273 participants | Moderate Downgraded: risk of bias, inconsistency |
Study withdrawal due to adverse events SSRI vs placebo | RR 3.8 [2.61, 5.51] | 20 studies · 7367 participants | Low Downgraded: risk of bias |
Perceived control over ejaculation SSRI vs placebo | RR 2.29 [1.72, 3.05] | 3 studies · 4273 participants | Moderate Downgraded: risk of bias |
Participant distress about PE SSRI vs placebo | RR 1.54 [1.26, 1.88] | 1 study · 652 participants | Moderate Downgraded: risk of bias |
Adverse events SSRI vs placebo | RR 1.71 [1.48, 1.99] | 17 studies · 4624 participants | Moderate Downgraded: risk of bias |
IELT SSRI vs placebo | no estimate extracted | 20 studies · 5872 participants | Low Downgraded: risk of bias, inconsistency |