Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,918 questions · 5,537 findings · 1,803 reviews

No studies found 1,309 · 23.6%GRADE not reported 440 · 7.9%Very low 1,560 · 28.2%Low 1,292 · 23.3%Moderate 751 · 13.6%High 185 · 3.3%

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Intervention not reported

Total number of adverse events · adults with renal vasculitis

The intervention showed no clear difference in total number of adverse events (low certainty).

1 finding from 1 review

Usual care with ivabradine vs Placebo, no intervention or usual care (with or without placebo)

Rate of serious adverse events · adults (≥ 18 years of age) with a diagnosis of chronic heart failure with reduced ejection fraction (HFrEF)
2 findings from 1 review

Usual care with ivabradine vs Placebo, no intervention or usual care (with or without placebo)

Rate of serious adverse events · patients with chronic heart failure with preserved ejection fraction
2 findings from 1 review

Mirtazapine vs placebo

Safety Any serious adverse event · adults with fibromyalgia

It is very uncertain whether mirtazapine changes safety: serious adverse events compared with placebo (very low certainty).

1 finding from 1 review

Probiotics used as adjuvants to conventional antifungal drugs vs conventional antifungal drugs

Rate of serious adverse events · non‐pregnant women with vulvovaginal candidiasis

Probiotics used as adjuvants to conventional antifungal drugs showed no clear difference in rate of serious adverse events compared with conventional antifungal drugs (low certainty).

1 finding from 1 review

Larger coaxial microincision cataract surgery (C‐MICS) vs standard phacoemulsification

Adverse events (corneal edema) · people with age‐related cataract

Larger coaxial microincision cataract surgery (C‐MICS) led to higher adverse events (corneal edema) compared with standard phacoemulsification; GRADE not reported.

1 finding from 1 review