Cochrane · systematic review · CD012915
MVA85A vaccine to enhance BCG for preventing tuberculosis
Kashangura, R, Jullien, S, Garner, P, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Infectious DiseasesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 14.3%Moderate 4 · 57.1%High 2 · 28.6%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
MVA85A compared to placebo for preventing tuberculosis
Population: HIV‐positive and ‐negative adults and children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Active tuberculosis: confirmed by culture or Xpert® MTB/RIF longest reported MVA85A vs placebo | RR 0.97 [0.58, 1.62] | 2 studies · 3439 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Active tuberculosis: started on tuberculosis treatment MVA85A vs placebo | RR 1.1 [0.92, 1.33] | 3 studies · 3687 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Latent tuberculosis MVA85A vs placebo | RR 1.01 [0.85, 1.21] | 4 studies · 3831 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Serious adverse effects MVA85A vs placebo | RD 0 | 3 studies · 3692 participants | High |
Adverse effects of any severity (local reactions of the skin) MVA85A vs placebo | no estimate extracted | 3 studies · 3187 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Adverse effects of any severity (systemic symptoms) MVA85A vs placebo | no estimate extracted | 1 study · 144 participants | Low Downgraded: risk of bias, imprecision |
Adverse events of any severity MVA85A vs placebo | RR 1.05 [1.02, 1.08] | 4 studies · 3836 participants | High |