Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

1,949 questions · 1,994 findings · 636 reviews

No studies found 504 · 25.3%GRADE not reported 340 · 17.1%Very low 477 · 23.9%Low 390 · 19.6%Moderate 241 · 12.1%High 42 · 2.1%

Flunarizine vs placebo

Adverse effects ‐ Blurred vision No of patients with blurred vision · patients with drug‐resistant epilepsy

Flunarizine showed no clear difference in adverse effects ‐ Blurred vision No of patients with blurred vision compared with placebo (high certainty).

1 finding from 1 review

Brexpiprazole vs antidepressive agents

Adverse effects: 2. Extrapyramidal ‐ akathisia · participants of any age with a primary diagnosis of major depressive disorder

Brexpiprazole probably leads to higher adverse effects: akathisia (followed up until the end of the longest compared with antidepressive agents (moderate certainty).

1 finding from 1 review

Levetiracetam vs placebo

Adverse effects: 5 most common adverse effects (any age) – dizziness · people with drug‐resistant focal epilepsy

Levetiracetam showed no clear difference in adverse effects: 5 most common adverse effects (any age) – dizziness compared with placebo (moderate certainty).

1 finding from 1 review

Cooling treatment (ice pack) vs no treatment

Adverse effects on perineal wound healing: Day 5 ‐ Wound not healing · Women with perineal trauma (tear or episiotomy, or both) sustained during childbirth

It is very uncertain whether cooling treatment (ice pack or cold gel pad) changes adverse effects on perineal wound healing: Day 5 ‐ Wound not healing compared with no treatment (very low certainty).

1 finding from 1 review

Cooling treatment (ice pack) vs cooling treatment (cold gel pad)

Adverse effects on perineal wound healing: Day 5 ‐ Wound not healing · Women with perineal trauma (tear or episiotomy, or both) sustained during childbirth

It is very uncertain whether cooling treatment (ice pack) changes adverse effects on perineal wound healing: Day 5 ‐ Wound not healing compared with cooling treatment (cold gel pad) (very low certainty).

1 finding from 1 review

Zuclopenthixol dihydrochloride vs chlorpromazine

Adverse effects: Clinically important general adverse effect (EPSEs) · schizophrenia

It is very uncertain whether zuclopenthixol dihydrochloride changes adverse effects: Clinically important general adverse effect (EPSEs) compared with chlorpromazine (very low certainty).

1 finding from 1 review

PERPHENAZINE vs antipsychotics

Adverse events: extrapyramidal adverse effects ‐ dystonia ‐ short term · patients with schizophrenia

It is very uncertain whether PERPHENAZINE changes adverse events: extrapyramidal adverse effects dystonia ‐ short term compared with ANY ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

ASENAPINE vs placebo

Adverse effects: 1. Clinically significant extrapyramidal side effects (2‐10 weeks) vs. standard higher dose (> 7.5‐15 mg/day) · adults with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Azoles vs allylamines

Adverse effects Reported by investigators 'and' or 'or' participants · patients with tinea cruris and tinea corporis

It is very uncertain whether azoles changes adverse effects Reported by investigators 'and' or 'or' participants compared with allylamines (very low certainty).

1 finding from 1 review

Azoles vs moderate‐potent corticosteroid/azole combinations

Adverse effects Reported by investigators 'and' or 'or' participants · patients with tinea cruris and tinea corporis

It is very uncertain whether azoles changes adverse effects Reported by investigators 'and' or 'or' participants compared with moderate‐potent corticosteroid/azole combinations (very low certainty).

1 finding from 1 review

Azoles vs benzylamines

Adverse effects Reported by investigators 'and' or 'or' participants · patients with tinea cruris and tinea corporis

It is very uncertain whether azoles changes adverse effects Reported by investigators 'and' or 'or' participants compared with benzylamines (very low certainty).

1 finding from 1 review

Terbinafine 1% cream/gel vs Placebo (vehicle cream)

Adverse effects Reported by investigators 'and' or 'or' participants · patients with tinea cruris and tinea corporis

It is very uncertain whether terbinafine 1% cream/gel changes adverse effects Reported by investigators 'and' or 'or' participants compared with placebo cream/gel (very low certainty).

1 finding from 1 review

Azoles vs placebo

Adverse effects Reported by investigators 'and' or 'or' participants · patients with tinea cruris and tinea corporis

It is very uncertain whether azoles changes adverse effects Reported by investigators 'and' or 'or' participants compared with placebo (very low certainty).

1 finding from 1 review

Naftifine 1% cream once or twice daily vs placebo cream once or twice daily

Adverse effects Reported by investigators 'and' or 'or' participants · patients with tinea cruris and tinea corporis

It is very uncertain whether naftifine 1% cream once or twice daily changes adverse effects Reported by investigators 'and' or 'or' participants compared with placebo cream once or twice daily (very low certainty).

1 finding from 1 review

Levetiracetam vs placebo

Somnolence · people with drug‐resistant focal epilepsy

Levetiracetam probably leads to higher adverse effects: 5 most common adverse effects (any age) – somnolence compared with placebo (moderate certainty).

1 finding from 1 review

Cooling treatment (ice pack) vs no treatment

Adverse effects on perineal wound healing: Day 5 ‐ Wound edges gaping · Women with perineal trauma (tear or episiotomy, or both) sustained during childbirth

It is very uncertain whether cooling treatment (ice pack or cold gel pad) changes adverse effects on perineal wound healing: Day 5 ‐ Wound edges gaping compared with no treatment (very low certainty).

1 finding from 1 review

Cooling treatment (ice pack) vs cooling treatment (cold gel pad)

Adverse effects on perineal wound healing: Day 5 ‐ Wound edges gaping · Women with perineal trauma (tear or episiotomy, or both) sustained during childbirth

It is very uncertain whether cooling treatment (ice pack) changes adverse effects on perineal wound healing: Day 5 ‐ Wound edges gaping compared with cooling treatment (cold gel pad) (very low certainty).

1 finding from 1 review