Cochrane · systematic review · CD001901
Levetiracetam add‐on for drug‐resistant focal epilepsy
Mbizvo, GK, Chandrasekar, B, Nevitt, SJ, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
EpilepsyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 28.6%Moderate 4 · 57.1%High 1 · 14.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Levetiracetam compared to placebo for drug‐resistant focal epilepsy
Population: drug‐resistant focal epilepsy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
50% or greater reduction in focal seizure frequency (responders) intention to treat– all doses Levetiracetam vs placebo | RR 2.37 [2.02, 2.78] | 14 studies · 2455 participants | Moderate Downgraded: risk of bias, inconsistency |
Treatment withdrawal– all doses Levetiracetam vs placebo | RR 1.11 [0.89, 1.4] | 13 studies · 2428 participants | High |
Adverse effects: 5 most common adverse effects (any age) – somnolence Levetiracetam vs placebo | RR 1.62 [1.19, 2.2] | 13 studies · 2423 participants | Moderate Downgraded: risk of bias |
Adverse effects: 5 most common adverse effects (any age) – headache Levetiracetam vs placebo | RR 0.85 [0.6, 1.21] | 13 studies · 2423 participants | Low Downgraded: risk of bias, inconsistency |
Adverse effects: 5 most common adverse effects (any age) – dizziness Levetiracetam vs placebo | RR 1.54 [0.99, 2.42] | 13 studies · 2423 participants | Moderate Downgraded: risk of bias |
Adverse effects: 5 most common adverse effects (any age) – fatigue (asthenia) Levetiracetam vs placebo | RR 1.53 [0.98, 2.38] | 13 studies · 2423 participants | Moderate Downgraded: risk of bias |
Adverse effects: 5 most common adverse effects (any age) – accidental injury Levetiracetam vs placebo | RR 0.72 [0.49, 1.06] | 13 studies · 2423 participants | Low Downgraded: risk of bias, inconsistency |