Non-Cochrane · aetiology · PM42410842
Correlation between temporomandibular disorders and the history of orthodontic treatment: A systematic review and meta-analysis.
Lang Xin, Guo Ge, He Zhengquan · Medicine · 2026 · PubMed · doi:10.1097/md.0000000000049626
Findings
Population Adults (18 years or older) with or without temporomandibular disorders
5 findings
| History of completed orthodontic treatment | No history of orthodontic treatment | Occurrence/correlation of temporomandibular disorders (TMDs) At most recent examination (prospective follow-up 30 months to 20 years) · Not specified · Sensitivity analysis: Shalish 2024 excluded | OR 1.48 [1.15, 1.91] GRADE not reported 4 studies · 6680 participants |
| History of completed orthodontic treatment | No history of orthodontic treatment | Occurrence/correlation of temporomandibular disorders (TMDs) At most recent examination (prospective follow-up 30 months to 20 years) · Not specified · Overall (all 5 studies) | OR 1.12 [0.67, 1.89] 9 [-27, 65] per 1000 (more) Very low Downgraded: inconsistency, indirectness 5 studies · 6971 participants |
| History of completed orthodontic treatment | No history of orthodontic treatment | Occurrence/correlation of temporomandibular disorders (TMDs) At most recent examination (prospective follow-up 30 months to 20 years) · Not specified · Subgroup: cross-sectional study (single study) | OR 1.61 [1.18, 2.20] GRADE not reported 1 study · 5567 participants |
| History of completed orthodontic treatment | No history of orthodontic treatment | Occurrence/correlation of temporomandibular disorders (TMDs) At most recent examination (prospective follow-up 30 months to 20 years) · Not specified · Subgroup: case-control studies | OR 0.82 [0.38, 1.75] GRADE not reported 2 studies · 893 participants |
| History of completed orthodontic treatment | No history of orthodontic treatment | Occurrence/correlation of temporomandibular disorders (TMDs) At most recent examination (prospective follow-up 30 months to 20 years) · Not specified · Subgroup: prospective cohort studies | OR 1.71 [0.55, 5.30] GRADE not reported 2 studies · 511 participants |
Included primary studies 5
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Macfarlane 2009 Twenty-year cohort study of health gain from orthodontic treatment: temporomandibular disorders. PMID:19524817 | 2009 | this review only | Occurrence/correlation of temporomandibular disorders (TMDs) | not extracted yet |
| Manfredini 2016 Orthodontics is temporomandibular disorder-neutral. PMID:26512757 | 2016 | this review only | Occurrence/correlation of temporomandibular disorders (TMDs) | not extracted yet |
| Shalish 2024 The association between orthodontic treatment and temporomandibular disorders diagnosis and disease characteristics. PMID:38054581 | 2024 | this review only | Occurrence/correlation of temporomandibular disorders (TMDs) | not extracted yet |
| Sim 2019 Investigation of the association between orthodontic treatment and temporomandibular joint pain and dysfunction in the South Korean… PMID:31149608 | 2019 | this review only | Occurrence/correlation of temporomandibular disorders (TMDs) | not extracted yet |
| Slade 2008 Orthodontic Treatment, Genetic Factors and Risk of Temporomandibular Disorder. PMID:18663384 | 2008 | this review only | Occurrence/correlation of temporomandibular disorders (TMDs) | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Adults (18 years or older at last clinical evaluation) with clear TMD diagnosis including clinical examination; groups comparable in gender or adjusted | Adults, 6971 participants (3165 male, 3806 female) (n=5) |
| Intervention | History of completed orthodontic treatment (exposure) | History of orthodontic treatment (n=5) |
| Comparison | No history of orthodontic treatment | No history of orthodontic treatment (n=5) |
| Outcomes | Occurrence and development of TMDs (OR) | TMDs, OR (n=5) |
| Study designs | Randomized controlled trials and non-randomized controlled studies | 2 prospective cohort, 2 case-control, 1 cross-sectional (n=5); no RCTs |
| Timing | Not specified | Follow-up 30 months and 20 years in the 2 cohort studies |