Non-Cochrane · intervention · PM41733459
Effect of Different Sodium Hypochlorite Concentrations on Post Endodontic Pain: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Teja Kavalipurapu Venkata, Vasundhara Kaligotla Apoorva, Patini Romeo, et al. · Clinical and experimental dental research · 2026 · PubMed · doi:10.1002/cre2.70320
Findings
Population Adults (>18 years) with non-vital teeth or irreversible pulpitis undergoing non-surgical root canal treatment
3 findings
| Low concentration sodium hypochlorite irrigation (0.5% to 2.5%) | High concentration sodium hypochlorite irrigation (5% to 8.25%) | Post-operative pain occurrence (any pain vs none) at 24 h 24 h after root canal treatment | OR 0.69 [0.23, 2.09] Moderate Downgraded: imprecision, inconsistency 4 studies · 480 participants |
| Low concentration sodium hypochlorite irrigation (0.5% to 2.5%) | High concentration sodium hypochlorite irrigation (5% to 8.25%) | Post-operative pain occurrence (any pain vs none) at 72 h 72 h after root canal treatment | OR 0.73 [0.12, 4.34] Moderate Downgraded: imprecision, inconsistency 4 studies · 480 participants |
| Low concentration sodium hypochlorite irrigation (0.5% to 2.5%) | High concentration sodium hypochlorite irrigation (5% to 8.25%) | Post-operative pain occurrence (any pain vs none) at 48 h 48 h after root canal treatment | OR 0.56 [0.11, 2.76] Moderate Downgraded: imprecision, inconsistency 4 studies · 480 participants |
Included primary studies 7
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Mokhtari 2023 The effect of different concentrations and temperatures of sodium hypochlorite irrigation on pain intensity following endodontic treatment… PMID:37345724 | 2023 | 2 other reviews | not stated | not extracted yet |
| Verma 2019 Effect of Different Concentrations of Sodium Hypochlorite on Outcome of Primary Root Canal Treatment: A Randomized Controlled Trial. PMID:30827769 | 2019 | 1 other review | Post-operative pain occurrence (any pain vs none) at 24 h; Post-operative pain occurrence (any pain vs none) at 48 h; Post-operative pain occurrence (any pain vs none) at 72 h | not extracted yet |
| Demenech 2021 Postoperative Pain after Endodontic Treatment under Irrigation with 8.25% Sodium Hypochlorite and Other Solutions: A Randomized Clinical… PMID:33607121 | 2021 | this review only | Post-operative pain occurrence (any pain vs none) at 24 h; Post-operative pain occurrence (any pain vs none) at 48 h; Post-operative pain occurrence (any pain vs none) at 72 h | not extracted yet |
| Farzaneh 2018 Effect of two different concentrations of sodium hypochlorite on postoperative pain following single-visit root canal treatment: a… PMID:28134983 | 2018 | this review only | Post-operative pain occurrence (any pain vs none) at 24 h; Post-operative pain occurrence (any pain vs none) at 48 h; Post-operative pain occurrence (any pain vs none) at 72 h | not extracted yet |
| Mostafa 2020 Postoperative pain following endodontic irrigation using 1.3% versus 5.25% sodium hypochlorite in mandibular molars with necrotic pulps: a… PMID:31563148 | 2020 | this review only | not stated | not extracted yet |
| Ulin 2020 Immediate clinical and microbiological evaluation of the effectiveness of 0.5% versus 3% sodium hypochlorite in root canal treatment: A… PMID:31808947 | 2020 | this review only | not stated | not extracted yet |
| Vitali 2024 Postoperative pain after endodontic treatment using 8.25% vs 2.5% sodium hypochlorite in necrotic mandibular molars with apical… PMID:38819357 | 2024 | this review only | Post-operative pain occurrence (any pain vs none) at 24 h; Post-operative pain occurrence (any pain vs none) at 48 h; Post-operative pain occurrence (any pain vs none) at 72 h | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Healthy subjects > 18 years old | Adults undergoing non-surgical root canal treatment of non-vital teeth or teeth with irreversible pulpitis (n=7 RCTs; 1,109 patients; meta-analysis n=4, 480 patients) |
| Intervention | Root canal treatment of teeth with necrosis or irreversible pulpitis | Low concentration NaOCl 0.5% to 2.5% (n=7) |
| Comparison | Different concentrations of sodium hypochlorite used during root canal treatment | High concentration NaOCl 5% to 8.25% (n=7) |
| Outcomes | Post-operative pain incidence | Postoperative pain occurrence at 24, 48 and 72 h (meta-analysis n=4) |
| Study designs | Randomized clinical trials | RCTs (n=7) |
| Timing | Not specified | Pain assessed up to 7 days (up to 30 days in one study); meta-analysis at 24, 48 and 72 h |