Primary study · included by 1 review

Postoperative pain after endodontic treatment using 8.25% vs 2.5% sodium hypochlorite in necrotic mandibular molars with apical periodontitis: A randomized double-blind clinical trial.

Vitali 2024 · Vitali Filipe Colombo, Santos Pablo Silveira, Garcia Lucas da Fonseca Roberti, et al. · Journal of the American Dental Association (1939) · 2024

Included by

Effect of Different Sodium Hypochlorite Concentrations on Post Endodontic Pain: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Non-Cochrane · intervention · 2026 · cited as Vitali 2024 · Table 2; Study Selection; References; Figures 4-6

Outcome this study informs	Pooled effect	Evidence	Certainty
Post-operative pain occurrence (any pain vs none) at 24 h Low concentration sodium hypochlorite irrigation (0.5% to 2.5%) vs High concentration sodium hypochlorite irrigation (5% to 8.25%) · 24 h after root canal treatment	OR 0.69 [0.23, 2.09]	4 studies · 480 participants	Moderate
Post-operative pain occurrence (any pain vs none) at 72 h Low concentration sodium hypochlorite irrigation (0.5% to 2.5%) vs High concentration sodium hypochlorite irrigation (5% to 8.25%) · 72 h after root canal treatment	OR 0.73 [0.12, 4.34]	4 studies · 480 participants	Moderate
Post-operative pain occurrence (any pain vs none) at 48 h Low concentration sodium hypochlorite irrigation (0.5% to 2.5%) vs High concentration sodium hypochlorite irrigation (5% to 8.25%) · 48 h after root canal treatment	OR 0.56 [0.11, 2.76]	4 studies · 480 participants	Moderate

1 including review in total.