Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

63 questions · 63 findings · 19 reviews · Neonatal · Headline outcomes only

No studies found 9 · 14.3%GRADE not reported 5 · 7.9%Very low 18 · 28.6%Low 23 · 36.5%Moderate 8 · 12.7%High 0 · 0%

Opioids vs other analgesics

Hypotension · procedural pain in neonates

It is very uncertain whether opioids changes hypotension compared with other analgesics (very low certainty).

1 finding from 1 review

Intervention not reported

Hypotension requiring medical therapy (vasopressors or fluid boluses), occurring during the procedure No. of participants: 124(1 RCT) · Procedural pain in neonates

It is very uncertain whether the intervention changes hypotension requiring medical therapy (vasopressors or fluid… (very low certainty).

1 finding from 1 review

Intervention not reported

Duration of neonatal intensive care unit stay (hours or days) · preterm infants less than 30 weeks' gestational age requiring conventional mechanical ventilation for respiratory distress syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Tracheal suction vs no tracheal suction

Persistent pulmonary hypertension · non‐vigorous neonates born through meconium‐stained amniotic fluid

It is very uncertain whether tracheal suction changes persistent pulmonary hypertension (PPHN) compared with no tracheal suction (very low certainty).

1 finding from 1 review

Systemic administration of beta‐blockers vs placebo or no treatment

Arterial hypotension and/or bradycardia requiring treatment · Prevention of retinopathy of prematurity in preterm infants

Systemic administration of beta‐blockers may leads to higher arterial hypotension and/or bradycardia requiring treatment compared with placebo or no treatment (low certainty).

1 finding from 1 review