Cochrane · systematic review · CD004339
Arginine supplementation for prevention of necrotising enterocolitis in preterm infants
Shah, PS, Shah, VS, Kelly, LE · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 16.7%Moderate 5 · 83.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Arginine compared with placebo for prevention of necrotising enterocolitis
Population: prevention of necrotising enterocolitis in preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
NEC any stage Bell's criteria Arginine vs placebo | RR 0.38 [0.23, 0.64] | 3 studies · 285 participants | Moderate Downgraded: imprecision, indirectness |
Stage 1 NEC Bell's criteria Arginine vs placebo | RR 0.37 [0.15, 0.9] | 3 studies · 285 participants | Moderate Downgraded: imprecision, indirectness |
Stage 2 NEC Bell's criteria Arginine vs placebo | RR 0.51 [0.25, 1.06] | 3 studies · 285 participants | Moderate Downgraded: imprecision, indirectness |
Stage 3 NEC Bell's criteria Arginine vs placebo | RR 0.13 [0.02, 1.03] | 3 studies · 285 participants | Moderate Downgraded: imprecision, indirectness |
Mortality due to any cause Arginine vs placebo | RR 0.77 [0.41, 1.45] | 3 studies · 285 participants | Low Downgraded: imprecision, inconsistency, indirectness |
Side effects ‐ hypotension Arginine vs placebo | RR 1.03 [0.41, 2.59] | 2 studies · 192 participants | Moderate Downgraded: imprecision, indirectness |