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What do systematic reviews say?

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Evidence found and GRADE certainty

462 questions · 474 findings · 56 reviews · Eyes and Vision · Headline outcomes only

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No studies found 147 · 31%GRADE not reported 15 · 3.2%Very low 89 · 18.8%Low 157 · 33.1%Moderate 52 · 11%High 14 · 3%

Surgery vs no surgery

Proportion of eyes with gain in VA by 0.3 logMAR or greater · people with epiretinal membrane

It is very uncertain whether surgery changes proportion of eyes with gain in VA by 0.3 logMAR or greater compared with no surgery (very low certainty).

1 finding from 1 review

Surgery vs no surgery

Proportion of eyes with loss in VA by 0.3 logMAR or greater · people with epiretinal membrane

Surgery may leads to lower proportion of eyes with loss in VA by 0.3 logMAR or greater compared with no surgery (low certainty).

1 finding from 1 review

Cataract surgery with Hydrus microstent vs cataract surgery alone

Proportion of participants who required further glaucoma surgery, including laser · people with cataracts and open angle glaucoma, many of whom had mild or moderate glaucoma, which was well‐controlled with medication

Cataract surgery with Hydrus microstent may leads to lower proportion of participants who required further glaucoma surgery,… compared with cataract surgery alone (low certainty).

1 finding from 1 review

Combined surgery vs phacoemulsification alone

Proportion using one or more medications at one year after surgery Number of participants · patients with eyes with cataract and glaucoma

Combined surgery may leads to lower proportion using one or more medications at one year after surgery… compared with phacoemulsification alone (low certainty).

1 finding from 1 review

Phacoemulsification + supraciliary microstent surgery vs phacoemulsification alone

Proportion of participants who required further glaucoma surgery, including laser · people with open‐angle glaucoma

Phacoemulsification + supraciliary microstent surgery showed no clear difference in proportion of participants who required further glaucoma surgeryat… compared with phacoemulsification alone (low certainty).

1 finding from 1 review

Surgery vs botulinum neurotoxin injections

Treatment success: improvement in the angle of strabismus at 6 months · children with infantile esotropia

It is very uncertain whether surgery changes treatment success: improvement in the angle of strabismus at 6 months compared with botulinum neurotoxin injections (very low certainty).

1 finding from 1 review

Immediate cataract surgery vs delayed cataract surgery

Development of choroidal neovascularization · people with cataract and age‐related macular degeneration

It is very uncertain whether immediate cataract surgery changes development of choroidal neovascularization compared with delayed cataract surgery (very low certainty).

1 finding from 1 review