Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

29 questions · 29 findings · 9 reviews · Headline outcomes only

No studies found 7 · 24.1%GRADE not reported 5 · 17.2%Very low 9 · 31%Low 6 · 20.7%Moderate 1 · 3.4%High 1 · 3.4%

Sugar vs placebo

Reduction in crying duration Difference before and after treatment (hours per day of crying) · infants with colic defined by recognised criteria

It is very uncertain whether sugar changes reduction in crying duration Difference before and after treatment… compared with placebo (very low certainty).

1 finding from 1 review

Systemic corticosteroids vs placebo

Participants with hyperglycemia "Transient hyperglycemia" or blood sugar increase ≥ 50 mg/dL · people with radicular low back pain (not due to spinal stenosis)

Systemic corticosteroids showed no clear difference in participants with hyperglycemia "Transient hyperglycemia" or blood… compared with placebo (low certainty).

1 finding from 1 review

Intervention not reported

NNS versus sugar

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

NNS versus sugar NNS: aspartame, saccharin, sodium‐cyclamate
1 finding from 1 review

Intervention not reported

Number of infants with hypoglycaemia Blood sugar level: glucose meter or laboratory‐based plasma glucose level · newborn infants who require a central venous catheter

The intervention leads to lower number of infants with hypoglycaemia Blood sugar level: glucose… (high certainty).

1 finding from 1 review