Cochrane · systematic review · CD009999
Pain‐relieving agents for infantile colic
Biagioli, E, Tarasco, V, Lingua, C, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Developmental, Psychosocial and Learning ProblemsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 4 · 57.1%Low 2 · 28.6%Moderate 1 · 14.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Simethicone versus placebo for infantile colic
Population: infants with infantile colic
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Reduction in crying duration Difference between final values (hours per day of crying) Simethicone vs placebo | no estimate extracted | 1 study · 27 participants | Very low Downgraded: risk of bias, imprecision |
Responders Number of infants who improved after treatment Simethicone vs placebo | RR 0.95 [0.73, 1.23] | 2 studies · 110 participants | Low Downgraded: risk of bias |
Herbal agents versus placebo for infantile colic
Population: patients with infantile colic
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Reduction in crying duration Difference before and after treatment (hours per day of crying) Herbal agents vs placebo | MD 1.33 [0.71, 1.96] | 3 studies · 279 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Responders Number of infants who improved after treatment Herbal agents vs placebo | RR 2.05 [1.56, 2.7] | 3 studies · 277 participants | Moderate Downgraded: risk of bias |
Sugar versus placebo for infantile colic
Population: infants with infantile colic
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Reduction in crying duration Difference before and after treatment (hours per day of crying) Sugar vs placebo | MD 1.72 [1.38, 2.06] | 1 study · 70 participants | Very low Downgraded: risk of bias, imprecision |
Cimetropium bromide versus placebo for infantile colic
Population: infants with infantile colic
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Reduction in crying duration Difference between final values (minutes per crisis of crying) Cimetropium bromide vs placebo | no estimate extracted | 1 study · 86 participants | Very low Downgraded: risk of bias, imprecision |
Responders Number of infants who improved after treatment Cimetropium bromide vs placebo | RR 2.29 [1.44, 3.64] | 1 study · 86 participants | Very low Downgraded: risk of bias, imprecision |