Cochrane · systematic review · CD012885
Non‐nutritive sweeteners for diabetes mellitus
Lohner, S, Kuellenberg de Gaudry, D, Toews, I, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
Metabolic and Endocrine DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
13
current version
GRADE rated
5
No studies
7
Included studies
NR
No studies 7 · 53.8%Ungraded 1 · 7.7%Very low 5 · 38.5%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Non‐nutritive sweeteners for diabetes mellitus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Health‐related quality of life | no estimate extracted | NR | No studies |
Diabetes complications | no estimate extracted | NR | No studies |
All‐cause mortality | no estimate extracted | NR | No studies |
NNS versus sugar | no estimate extracted | NR | No studies |
NNS versus placebo NNS: aspartame, rebaudioside A, steviol glycoside | RR 0.78 [0.39, 1.56] | 3 studies · 231 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
NNS versus nutritive, low‐calorie sweetener | no estimate extracted | NR | No studies |
HbA1c (%) | no estimate extracted | 1 participants | Ungraded |
NNS versus sugar NNS: aspartame, saccharin, sodium‐cyclamate | no estimate extracted | 3 studies · 72 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
NNS versus placebo NNS: aspartame, rebaudioside A, steviol glycoside | no estimate extracted | 4 studies · 360 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
NNS versus nutritive, low‐calorie sweetener (tagatose) NNS: sucralose | no estimate extracted | 1 study · 354 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Body weight (kg) | no estimate extracted | NR | No studies |
NNS versus placebo NNS: aspartame, rebaudioside A | no estimate extracted | 2 studies · 184 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Socioeconomic effects | no estimate extracted | NR | No studies |