Cochrane · systematic review · CD010336
Antibiotic lock for the prevention of catheter‐related infection in neonates
Taylor, JE, Tan, K, Lai, NM, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 20%Low 0 · 0%Moderate 1 · 20%High 3 · 60%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Antibiotic lock for the prevention of catheter‐related sepsis in neonates
Population: newborn infants who require a central venous catheter
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
CRBSI (confirmed) Clinical and microbiological assessments | RR 0.15 [0.06, 0.4] | 3 studies · 271 participants | High |
CRBSI (suspected) Clinical assessment | RR 0.65 [0.22, 1.92] | 3 studies · 271 participants | Moderate |
Total CRBSI (confirmed and suspected) Clinical and microbiological assessments | RR 0.25 [0.12, 0.49] | 3 studies · 271 participants | High |
Mortality Clinical assessment | RR 0.12 [0.01, 2.13] | 1 study · 103 participants | Very low Downgraded: risk of bias |
Number of infants with hypoglycaemia Blood sugar level: glucose meter or laboratory‐based plasma glucose level | RR 0.51 [0.28, 0.92] | 2 studies · 168 participants | High |