SERMS vs no treatment
- Selective estrogen receptor modulators (SERMs) for uterine leiomyomas 2012 · Cochrane Headline outcomes onlyno estimate extracted1 study · 23 participantsVery low
Letrozole with or without adjuncts leads to higher live birth rate compared with SERMs with or without adjuncts followed by timed intercourse (high certainty).
Letrozole with or without adjuncts showed no clear difference in ovarian hyperstimulation syndrome rate compared with SERMs with or without adjuncts followed by timed intercourse (high certainty).
Letrozole with or without adjuncts leads to higher clinical pregnancy rate compared with SERMs with or without adjuncts followed by timed intercourse (high certainty).
Letrozole with or without adjuncts showed no clear difference in miscarriage rate per pregnancy compared with SERMs with or without adjuncts followed by timed intercourse (high certainty).
Letrozole with or without adjuncts showed no clear difference in multiple pregnancy rate compared with SERMs with or without adjuncts followed by timed intercourse (high certainty).
The review found no eligible studies for this question.
It is very uncertain whether raloxifene changes adverse events ‐ pelvic pain compared with placebo (very low certainty).
It is very uncertain whether raloxifene changes adverse events ‐ ovarian cyst compared with placebo (very low certainty).
It is very uncertain whether raloxifene changes adverse events ‐ headache compared with placebo (very low certainty).
It is very uncertain whether raloxifene changes adverse events ‐ migraine compared with placebo (very low certainty).
It is very uncertain whether raloxifene changes adverse events ‐ depression compared with placebo (very low certainty).
It is very uncertain whether raloxifene changes biopsy‐proven recurrence of endometriosis compared with placebo (very low certainty).