Cochrane · systematic review · CD005287
Selective estrogen receptor modulators (SERMs) for uterine leiomyomas
Deng, L, Wu, T, Chen, XY, et al. · Cochrane Database of Systematic Reviews · 2012 · Cochrane Library
Gynaecology and FertilityAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 16.7%Low 5 · 83.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
SERMS compared to no treatment for uterine leiomyomas
Population: patients with uterine leiomyomas
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Percent change from baseline in leiomyoma size SERMS vs no treatment | no estimate extracted | 1 study · 23 participants | Very low Downgraded: risk of bias |
SERMS (raloxifene 60mg) compared to placebo for uterine leiomyomas
Population: patients with uterine leiomyomas
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Size (cm3) of leiomyoma SERMS (raloxifene 60mg) vs placebo | no estimate extracted | 1 study · 58 participants | Low Downgraded: risk of bias, imprecision |
Size (cm3) of leiomyoma SERMS (raloxifene 60mg) vs placebo | no estimate extracted | 1 study · 58 participants | Low Downgraded: risk of bias, imprecision |
Percent change from baseline in leiomyoma size in GHRH‐analogue treated women SERMS (raloxifene 60mg) vs placebo | no estimate extracted | 1 study · 91 participants | Low Downgraded: risk of bias, imprecision |
SERMS (raloxifene 180 mg) compared to placebo for uterine leiomyomas
Population: patients with uterine leiomyomas
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Size (cm3) of leiomyoma SERMS (raloxifene 180 mg) vs placebo | no estimate extracted | 1 study · 60 participants | Low Downgraded: risk of bias, imprecision |
Size (cm3) of leiomyoma SERMS (raloxifene 180 mg) vs placebo | no estimate extracted | 1 study · 59 participants | Low Downgraded: risk of bias, imprecision |