Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

309 questions · 325 findings · 45 reviews · Acute Respiratory Infections

No studies found 38 · 11.7%GRADE not reported 31 · 9.5%Very low 54 · 16.6%Low 78 · 24%Moderate 106 · 32.6%High 18 · 5.5%

Written information for patients (or parents of child patients) plus prescribing feedback to clinicians vs prescribing feedback alone

Antibiotics prescribed by clinicians · patients (or parents of child patients) with acute upper respiratory tract infections

Written information for patients (or parents of child patients) plus… may leads to higher antibiotics prescribed by clinicians compared with prescribing feedback alone (low certainty).

1 finding from 1 review

Continuous negative extrathoracic pressure ventilation vs control

Intermittent positive pressure ventilation during hospital stay · children with acute hypoxaemic respiratory failure

It is very uncertain whether continuous negative extrathoracic pressure ventilation changes intermittent positive pressure ventilation during hospital stay compared with control (very low certainty).

1 finding from 1 review

Antibiotics vs control ‐ primary outcomes

Prevention ‐ any AOM or CSOM during intervention · patients with the prevention of acute and chronic suppurative otitis media in children

Antibiotic probably leads to lower prevention ‐ any AOM or CSOM during intervention compared with control ‐ primary outcomes (moderate certainty).

1 finding from 1 review

Continuous positive airway pressure (CPAP) vs supportive treatment

Incidence of mechanical ventilation · children with acute bronchiolitis

Continuous positive airway pressure (CPAP) showed no clear difference in proportion of children requiring mechanical ventilation compared with supportive treatment (low certainty).

1 finding from 1 review

Continuous positive airway pressure (CPAP) vs supportive treatment

Change in respiratory rate at 20 minutes · children with acute bronchiolitis

Continuous positive airway pressure (CPAP) showed no clear difference in mean change in respiratory rate (breaths/min) compared with supportive treatment (low certainty).

1 finding from 1 review

Continuous negative extrathoracic pressure ventilation vs control

Less than 30% FiO2 after 1 hour of therapy · children with acute hypoxaemic respiratory failure

It is very uncertain whether continuous negative extrathoracic pressure ventilation changes less than 30% FiO2 after 1 hour of therapy compared with control (very low certainty).

1 finding from 1 review

Continuous negative extrathoracic pressure ventilation vs control

CPAP during hospital stay · children with acute hypoxaemic respiratory failure

It is very uncertain whether continuous negative extrathoracic pressure ventilation changes CPAP during hospital stay compared with control (very low certainty).

1 finding from 1 review

Probiotics vs placebo or no treatment

Number of participants who used prescribed antibiotics for acute URTIs · children, adults, and the elderly

Intention‐to‐treat analysis: probiotics probably leads to lower number of participants who used prescribed antibiotics for acute URTIs compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Intervention not reported

Antibiotic prescriptions (number of courses/person/year) **Corticosteroids not meta‐analysed · adults (> 18 years of age) with either COPD or recurrent acute exacerbations of chronic bronchitis

The intervention may leads to higher antibiotic prescriptions (number of courses/person/year)… (low certainty).

1 finding from 1 review