Cochrane · systematic review · CD010130
Biomarkers as point‐of‐care tests to guide prescription of antibiotics in people with acute respiratory infections in primary care
Smedemark, SA, Aabenhus, R, Llor, C, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
10
No studies
1
Included studies
NR
No studies 1 · 8.3%Ungraded 1 · 8.3%Very low 4 · 33.3%Low 1 · 8.3%Moderate 4 · 33.3%High 1 · 8.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsPoint‐of‐care biomarkers (C‐reactive protein) for infection compared with standard of care for guiding antibiotic therapy in acute respiratory infections
Population: people with acute respiratory infections
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of participants given an antibiotic prescription at index consultation  Point‐of‐care biomarkers (C‐reactive protein) for infection vs standard of care | no estimate extracted | 12 studies · 10218 participants | Moderate Downgraded: inconsistency |
Number of participants given an antibiotic prescription within 28 days Point‐of‐care biomarkers (C‐reactive protein) for infection vs standard of care | no estimate extracted | 7 studies · 5091 participants | High |
Clinical recovery within 7 days Point‐of‐care biomarkers (C‐reactive protein) for infection vs standard of care | no estimate extracted | 4 studies · 3104 participants | Moderate Downgraded: risk of bias |
Mortality within 28 days Point‐of‐care biomarkers (C‐reactive protein) for infection vs standard of care | no estimate extracted | 9 studies · 7737 participants | Low Downgraded: imprecision |
Number of participants in need of a hospital admission within 28 days Point‐of‐care biomarkers (C‐reactive protein) for infection vs standard of care | no estimate extracted | 10 studies · 7514 participants | Moderate Downgraded: imprecision |
Clinical recovery within 28 days Point‐of‐care biomarkers (C‐reactive protein) for infection vs standard of care | no estimate extracted | 5 studies · 2324 participants | Moderate Downgraded: risk of bias |
Point‐of‐care biomarkers (procalcitonin) for infection compared with standard of care for guiding antibiotic therapy in acute respiratory infections
Population: people with acute respiratory infections
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of participants given an antibiotic prescription at index consultation  Point‐of‐care biomarkers (procalcitonin) for infection vs standard of care | no estimate extracted | 1 study · 317 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Number of participants given an antibiotic prescription within 28 days Point‐of‐care biomarkers (procalcitonin) for infection vs standard of care | no estimate extracted | 1 study · 277 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Clinical recovery within 7 days Point‐of‐care biomarkers (procalcitonin) for infection vs standard of care | no estimate extracted | 1 study · 277 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Mortality within 28 days Point‐of‐care biomarkers (procalcitonin) for infection vs standard of care | no estimate extracted | 1 study · 277 participants | Ungraded |
Number of participants in need of a hospital admission within 28 days Point‐of‐care biomarkers (procalcitonin) for infection vs standard of care | no estimate extracted | 1 study · 277 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Clinical recovery within 28 days Point‐of‐care biomarkers (procalcitonin) for infection vs standard of care | no estimate extracted | NR | No studies |