Pregabalin 600 mg vs placebo
Patient Global Impression of Change much or very much improved · adults with moderate or severe pain associated with postherpetic neuralgia
1 finding from 1 review
- no estimate extractedStudies not reportedVery low
Findings
What do systematic reviews say?
329 questions · 334 findings · 45 reviews · Pain, Palliative and Supportive Care · Headline outcomes only
No studies found 65 · 19.5%GRADE not reported 14 · 4.2%Very low 100 · 29.9%Low 67 · 20.1%Moderate 59 · 17.7%High 29 · 8.7%
Pregabalin 300 mg vs placebo
Patient Global Impression of Change much or very much improved · adults with moderate or severe pain associated with painful diabetic neuropathy
1 finding from 1 review
- no estimate extracted5 studies · 1050 participantsModerate
Pregabalin 300 mg vs placebo
PGIC very much improved · adults with moderate or severe pain associated with painful diabetic neuropathy
1 finding from 1 review
- no estimate extracted2 studies · 501 participantsLow
Pregabalin 600 mg vs placebo
Patient Global Impression of Change much or very much improved · adults with moderate or severe pain associated with painful diabetic neuropathy
1 finding from 1 review
- no estimate extracted3 studies · 537 participantsModerate
Pregabalin 300 mg vs placebo
Patient Global Impression of Change much or very much improved · adults with moderate or severe pain associated with postherpetic neuralgia
1 finding from 1 review
- no estimate extracted3 studies · 568 participantsLow
Pregabalin 300 mg or 600 mg vs placebo
mg pregabalin · adults with moderate or severe neuropathic pain
2 findings from 1 review
- no estimate extracted300 participantsGRADE not reported
- no estimate extracted600 participantsGRADE not reported
Pregabalin vs placebo
Patient Global Impression of Change much or very much improved · children and adolescents with chronic non‐cancer pain
1 finding from 1 review
- Antiepileptic drugs for chronic non‐cancer pain in children and adolescents 2017 · Cochrane Headline outcomes onlyno estimate extracted1 study · 107 participantsVery low
Pregabalin vs placebo at end of treatment
Patient Global Impression of Change much or very much improved · patients with fibromyalgia
Pregabalin leads to higher patient Global Impression of Change of 'much' or 'very much' improved compared with placebo at end of treatment (high certainty).
1 finding from 1 review
- RR 1.38 [1.23, 1.55]5 studies · 3183 participantsHigh
Decompressive surgery plus radiotherapy vs radiotherapy
Ambulation · adults with metastatic extradural spinal cord compression (fit for surgery, paraplegic less than 48 hours, and without multiple discrete…
Decompressive surgery plus radiotherapy may leads to higher ambulation Immediately after completing RT compared with radiotherapy (low certainty).
1 finding from 1 review
- Interventions for the treatment of metastatic extradural spinal cord compression in adults 2015 · Cochrane Headline outcomes onlyRR 1.48 [1.16, 1.9]1 study · 101 participantsLow
Decompressive surgery plus radiotherapy vs radiotherapy
Survival (short term) At 30 days · adults with metastatic extradural spinal cord compression (fit for surgery, paraplegic less than 48 hours, and without multiple discrete…
Decompressive surgery plus radiotherapy showed no clear difference in survival (short term) At 30 days compared with radiotherapy (low certainty).
1 finding from 1 review
- Interventions for the treatment of metastatic extradural spinal cord compression in adults 2015 · Cochrane Headline outcomes onlyRR 1.09 [0.96, 1.24]1 study · 101 participantsLow
Decompressive surgery plus radiotherapy vs radiotherapy
Reduction in analgesic and narcotic use One month after radiation · adults with metastatic extradural spinal cord compression (fit for surgery, paraplegic less than 48 hours, and without multiple discrete…
1 finding from 1 review
- Interventions for the treatment of metastatic extradural spinal cord compression in adults 2015 · Cochrane Headline outcomes onlyno estimate extracted1 study · 101 participantsGRADE not reported
Decompressive surgery plus radiotherapy vs radiotherapy
Urinary continence 3 months after surgery MCID: 5% absolute difference · adults with metastatic extradural spinal cord compression (fit for surgery, paraplegic less than 48 hours, and without multiple discrete…
1 finding from 1 review
- Interventions for the treatment of metastatic extradural spinal cord compression in adults 2015 · Cochrane Headline outcomes onlyno estimate extracted1 study · 101 participantsGRADE not reported
Decompressive surgery plus radiotherapy vs radiotherapy
Local recurrence · adults with metastatic extradural spinal cord compression (fit for surgery, paraplegic less than 48 hours, and without multiple discrete…
The review found no eligible studies for this question.
1 finding from 1 review
- Interventions for the treatment of metastatic extradural spinal cord compression in adults 2015 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Decompressive surgery plus radiotherapy vs radiotherapy
Adverse events · adults with metastatic extradural spinal cord compression (fit for surgery, paraplegic less than 48 hours, and without multiple discrete…
1 finding from 1 review
- Interventions for the treatment of metastatic extradural spinal cord compression in adults 2015 · Cochrane Headline outcomes onlyno estimate extracted1 study · 101 participantsGRADE not reported
Decompressive surgery plus radiotherapy vs radiotherapy
Quality of life · adults with metastatic extradural spinal cord compression (fit for surgery, paraplegic less than 48 hours, and without multiple discrete…
The review found no eligible studies for this question.
1 finding from 1 review
- Interventions for the treatment of metastatic extradural spinal cord compression in adults 2015 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Summary of findings: serious adverse events (HEC) when vs treatment with aprepitant + granisetron
aprepitant + ondansetron · adult cancer patients at risk for CINV caused by highly emetogenic chemotherapy
1 finding from 1 review
- Antiemetics for adults for prevention of nausea and vomiting caused by moderately or highly emetogenic chemotherapy: a… 2021 · Cochrane Headline outcomes onlyno estimate extracted23 studies · 16065 participantsVery low
Summary of findings: serious adverse events (HEC) when vs treatment with aprepitant + granisetron
fosaprepitant + ondansetron · adult cancer patients at risk for CINV caused by highly emetogenic chemotherapy
1 finding from 1 review
- Antiemetics for adults for prevention of nausea and vomiting caused by moderately or highly emetogenic chemotherapy: a… 2021 · Cochrane Headline outcomes onlyno estimate extracted23 studies · 16065 participantsLow
Summary of findings: serious adverse events (HEC) when vs treatment with aprepitant + granisetron
aprepitant + ramosetron · adult cancer patients at risk for CINV caused by highly emetogenic chemotherapy
1 finding from 1 review
- Antiemetics for adults for prevention of nausea and vomiting caused by moderately or highly emetogenic chemotherapy: a… 2021 · Cochrane Headline outcomes onlyno estimate extracted23 studies · 16065 participantsVery low
Summary of findings: serious adverse events (HEC) when vs treatment with aprepitant + granisetron
fosaprepitant + palonosetron · adult cancer patients at risk for CINV caused by highly emetogenic chemotherapy
1 finding from 1 review
- Antiemetics for adults for prevention of nausea and vomiting caused by moderately or highly emetogenic chemotherapy: a… 2021 · Cochrane Headline outcomes onlyno estimate extracted23 studies · 16065 participantsVery low
Summary of findings: serious adverse events (HEC) when vs treatment with aprepitant + granisetron
fosaprepitant + granisetron · adult cancer patients at risk for CINV caused by highly emetogenic chemotherapy
1 finding from 1 review
- Antiemetics for adults for prevention of nausea and vomiting caused by moderately or highly emetogenic chemotherapy: a… 2021 · Cochrane Headline outcomes onlyno estimate extracted23 studies · 16065 participantsLow