Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

256 questions · 278 findings · 34 reviews · ENT

No studies found 86 · 30.9%GRADE not reported 1 · 0.4%Very low 88 · 31.7%Low 66 · 23.7%Moderate 35 · 12.6%High 2 · 0.7%

Capsaicin vs placebo

Resolution of symptoms · non‐allergic rhinitis

Capsaicin may leads to higher daily record chart symptom resolution 4 weeks post‐treatment… compared with placebo (low certainty).

1 finding from 1 review

Tranexamic acid vs placebo (saline solution or sterile water)

Significant adverse events (seizures, thromboembolism) within 24 hours of surgery) · adults and children with chronic rhinosinusitis with or without nasal polyps

Tranexamic acid showed no clear difference in significant adverse events (seizures, thromboembolism) within 24… compared with placebo (saline solution or sterile water) (moderate certainty).

1 finding from 1 review

Tranexamic acid vs placebo (saline solution or sterile water)

Overall rate of surgical complications · adults and children with chronic rhinosinusitis with or without nasal polyps

Tranexamic acid showed no clear difference in surgical complications compared with placebo (saline solution or sterile water) (moderate certainty).

1 finding from 1 review

Tranexamic acid vs placebo (saline solution or sterile water)

Postoperative bleeding (place of packing or revision surgery within 14 days of surgery) · adults and children with chronic rhinosinusitis with or without nasal polyps

Tranexamic acid showed no clear difference in postoperative bleeding (place of packing or revision surgery within… compared with placebo (saline solution or sterile water) (low certainty).

1 finding from 1 review

Betahistine vs placebo/no treatment

Improvement in vertigo frequency · Ménière’s disease

It is very uncertain whether betahistine changes improvement in vertigo frequency compared with placebo/no treatment (very low certainty).

2 findings from 1 review