Cochrane · systematic review · CD015171
Systemic pharmacological interventions for Ménière’s disease
Webster, KE, Galbraith, K, Harrington-Benton, NA, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
ENTAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 8 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Betahistine compared to placebo/no treatment for Ménière’s disease
Population: Ménière’s disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Improvement in vertigo frequency Betahistine vs placebo/no treatment | RR 1.5 [0.98, 2.29] | 1 study · 70 participants | Very low Downgraded: risk of bias |
Improvement in vertigo frequency Betahistine vs placebo/no treatment | RR 1.11 [0.93, 1.32] | 1 study · 62 participants | Very low Downgraded: risk of bias, imprecision |
Vertigo global score Betahistine vs placebo/no treatment | no estimate extracted | 1 study · 34 participants | Very low Downgraded: risk of bias, imprecision |
Change in vertigo frequency Betahistine vs placebo/no treatment | no estimate extracted | 2 studies · 117 participants | Very low Downgraded: risk of bias, imprecision |
Change in vertigo frequency Betahistine vs placebo/no treatment | no estimate extracted | 1 study · 214 participants | Very low Downgraded: risk of bias, imprecision |
Serious adverse events Betahistine vs placebo/no treatment | RR 1.2 [0.63, 2.29] | 1 study · 220 participants | Very low Downgraded: risk of bias, imprecision |
Diuretic compared to placebo/no treatment for Ménière’s disease
Population: Ménière’s disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Improvement in vertigo frequency Diuretic vs placebo/no treatment | RR 1.69 [1.13, 2.53] | 1 study · 70 participants | Very low Downgraded: risk of bias |
Change in vertigo frequency Diuretic vs placebo/no treatment | no estimate extracted | 1 study · 220 participants | Very low Downgraded: risk of bias, imprecision |