Cochrane · systematic review · CD010591
Capsaicin for non‐allergic rhinitis
Gevorgyan, A, Segboer, C, Gorissen, R, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
ENTAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
5
No studies
3
Included studies
NR
No studies 3 · 37.5%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 37.5%Moderate 2 · 25%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Capsaicin compared to placebo for non‐allergic rhinitis
Population: non‐allergic rhinitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall nasal symptom score 36 weeks post‐treatment Capsaicin vs placebo | no estimate extracted | 1 study · 24 participants | Moderate Downgraded: imprecision |
Daily record chart symptom resolution 4 weeks post‐treatment (capsaicin 4 μg/puff versus placebo) Capsaicin vs placebo | RR 3.17 [1.38, 7.29] | 1 study · 104 participants | Low |
Treatment‐related adverse events Capsaicin vs placebo | no estimate extracted | NR | No studies |
Capsaicin compared to budesonide for non‐allergic rhinitis
Population: patients with non‐allergic rhinitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Nasal obstruction during the 4th week of treatment Number of responders Capsaicin vs budesonide | RR 1.11 [0.93, 1.31] | 1 study · 40 participants | Low Downgraded: imprecision |
Aggregate relief score during the 4th week of treatment Capsaicin vs budesonide | no estimate extracted | 1 study · 40 participants | Low Downgraded: imprecision |
Treatment‐related adverse events Capsaicin vs budesonide | no estimate extracted | NR | No studies |
Five capsaicin treatments in one day compared to daily capsaicin treatment for five days for non‐allergic rhinitis
Population: patients with non‐allergic rhinitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Smell testing University of Pennsylvania Smell Identification Test (UPSIT) Scale from: 0 to 40 Five capsaicin treatments in one day vs daily capsaicin treatment | no estimate extracted | 1 study · 30 participants | Moderate Downgraded: imprecision |
Treatment‐related adverse events Five capsaicin treatments in one day vs daily capsaicin treatment | no estimate extracted | NR | No studies |