Oral health-related quality of life · Children with dental caries
The direct estimate found no statistically significant difference in oral health-related quality of life between placebo and silver diamine fluoride.
2 findings from 1 review
Caries increment in permanent teeth · Children or adolescents
The NMR reported an SMD by randomisation year; no GRADE assessment was reported.
1 finding from 1 review
Caries increment, surface index D(M)FS · Children or adolescents
In the illustrative network meta-regression the SMD for caries increment differed between placebo and no treatment at randomization years 1970 to 1990; certainty was not graded.
1 finding from 1 review
Lactobacillus count (pre- vs post-treatment) · Medically healthy individuals (adults and children, 6-60 years)
Placebo rinse did not significantly change Lactobacillus counts relative to baseline; not GRADE-rated.
1 finding from 1 review
Plaque · Medically healthy individuals (adults and children, 6-60 years)
Placebo rinse did not significantly change plaque relative to baseline; not GRADE-rated.
1 finding from 1 review
Streptococcus mutans count · Medically healthy individuals (adults and children, 6-60 years)
Placebo rinse did not significantly change Streptococcus mutans counts relative to baseline; not GRADE-rated.
1 finding from 1 review
Coronal carious lesions prevention · Children with coronal carious lesions (primary dentition)
One review reported a 54% prevented fraction for fluoride varnish versus placebo for preventing coronal caries in primary teeth (one study; ungraded; comparator intervention, not SDF).
1 finding from 1 review
Prevented Fraction 54
1 study
GRADE not reported
Maximum pain (verbal rating scale, VRS) · People requiring retreatment of periapical lesions (failed root canal therapy)
Placebo (sham irradiation, laser inactive) led to lower maximum pain (verbal rating scale, VRS) compared with control (no laser device used); GRADE not reported.
1 finding from 1 review
Streptococcus mutans colonization reduction (narrative; no CFU data reported) · Animal caries models (mice, rats, hamsters) challenged/colonized with Streptococcus mutans; one transgenic-plant antigen-expression system
Anticaries vaccines produced a sustained reduction in Streptococcus mutans colonization on teeth in animal models (ungraded narrative synthesis; no pooled estimate).
1 finding from 1 review
no estimate extracted
Studies not reported
GRADE not reported
Treatment success (caries lesion arrest or restoration survival) · Children (aged 3-11 y) with cavitated caries lesions in primary teeth
At 6 months, the Hall technique had significantly higher treatment success than placebo (OR 163.59; moderate certainty).
1 finding from 1 review
Incidence of initial caries around brackets, aesthetic-zone teeth only · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
When only aesthetic-zone teeth (incisors and canines) were considered, two studies reported a significant reduction in initial caries incidence favoring fluoride mouthrinse (ungraded, narrative; no pooled estimate).
1 finding from 1 review
Salivary / secretory IgA (SIgA) antibody response (immunogenicity) · Animal caries models (mice, rats, hamsters) challenged/colonized with Streptococcus mutans; one transgenic-plant antigen-expression system
Anticaries vaccines, particularly via mucosal (intranasal) routes, elicited increased salivary/secretory IgA responses in the animal studies (ungraded narrative synthesis; no pooled estimate).
1 finding from 1 review
no estimate extracted
Studies not reported
GRADE not reported
Improved caries prognosis via restored oral microbiota · Patients after dental filling
Adjuvant postbiotics after dental filling improve caries prognosis by restoring the oral microbiota in one RCT (ungraded).
1 finding from 1 review
Treatment success (caries lesion arrest or restoration survival) · Children (aged 3-11 y) with cavitated caries lesions in primary teeth
At 6 months, ART had significantly higher treatment success than placebo (OR 16.18).
1 finding from 1 review
OR 16.18 [1.21, 215.73]
44 studies
GRADE not reported
Serum IgG antibody response (immunogenicity) · Animal caries models (mice, rats, hamsters) challenged/colonized with Streptococcus mutans; one transgenic-plant antigen-expression system
Anticaries vaccines elicited increased serum IgG antibody responses across the animal studies (ungraded narrative synthesis; no pooled estimate).
1 finding from 1 review
no estimate extracted
Studies not reported
GRADE not reported
Treatment success (caries lesion arrest or restoration survival) · Children (aged 3-11 y) with cavitated caries lesions in primary teeth
At 6 months, conventional restorations had significantly higher treatment success than placebo (OR 44.66).
1 finding from 1 review
OR 44.66 [3.22, 620.47]
44 studies
Moderate
Incidence of proximal (interdental) caries lesions from bitewing radiographs · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
Only one included study assessed proximal caries incidence from bitewing radiographs; it was not included in the meta-analysis and no pooled estimate is available (ungraded).
1 finding from 1 review
Reduced dental plaque index · Adults with dental caries
Postbiotic lozenges reduce plaque index in one adult RCT (ungraded).
1 finding from 1 review
Streptococcus mutans count · Humans at risk of dental caries (children aged 6-12 years; adults with dental caries)
Postbiotic products reduce salivary S. mutans counts in human trials, though not always significantly (ungraded narrative synthesis).
1 finding from 1 review
Development of >=1 new carious lesion (caries incidence) · Animal caries models (mice, rats, hamsters) challenged/colonized with Streptococcus mutans; one transgenic-plant antigen-expression system
In preclinical animal models, anticaries vaccines significantly reduced dental caries risk (pooled RR 0.53, 95% CI 0.46 to 0.62; random-effects), but the evidence is ungraded and limited to short-term animal studies.
1 finding from 1 review
RR 0.53 [0.46, 0.62]
Studies not reported
GRADE not reported