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Evidence found and GRADE certainty

45 questions · 46 findings · 13 reviews · Emergency and Critical Care · Headline outcomes only

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No studies found 2 · 4.3%GRADE not reported 3 · 6.5%Very low 15 · 32.6%Low 15 · 32.6%Moderate 11 · 23.9%High 0 · 0%

Oxygenation vs no oxygenation during the apnoeic period preceding intubation

Incidence of severe hypoxaemia (SpO2 < 80%) · people requiring tracheal intubation

Oxygenation showed no clear difference in incidence of severe hypoxaemia (SpO2 < 80%) compared with no oxygenation during the apnoeic period preceding intubation (low certainty).

1 finding from 1 review

Oxygenation vs no oxygenation during the apnoeic period preceding intubation

Hypoxaemia · people requiring tracheal intubation

Oxygenation showed no clear difference in incidence of hypoxaemia (SpO2 < 93%) compared with no oxygenation during the apnoeic period preceding intubation (low certainty).

1 finding from 1 review

Oxygenation vs no oxygenation during the apnoeic period preceding intubation

First‐pass success of cannulation · people requiring tracheal intubation

Oxygenation showed no clear difference in first pass success rate compared with no oxygenation during the apnoeic period preceding intubation (moderate certainty).

1 finding from 1 review

Oxygenation vs no oxygenation during the apnoeic period preceding intubation

All‐cause mortality · people requiring tracheal intubation

Oxygenation showed no clear difference in mortality compared with no oxygenation during the apnoeic period preceding intubation (low certainty).

1 finding from 1 review

Summary of findings table ‐ Extracorporeal membrane oxygenation (ECMO) vs usual care

All‐cause mortality: all ECMO studies · severe cardiorespiratory failure and cardiac arrest

Summary of findings table ‐ Extracorporeal membrane oxygenation (ECMO) probably leads to lower all‐cause mortality: all ECMO studies compared with conventional care (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Extracorporeal membrane oxygenation (ECMO) vs usual care

All‐cause mortality: VV ECMO subgroup · severe cardiorespiratory failure and cardiac arrest

Summary of findings table ‐ Extracorporeal membrane oxygenation (ECMO) probably leads to lower all‐cause mortality: VV ECMO subgroup compared with conventional care (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Extracorporeal membrane oxygenation (ECMO) vs usual care

All‐cause mortality: VA ECMO subgroup · severe cardiorespiratory failure and cardiac arrest

Summary of findings table ‐ Extracorporeal membrane oxygenation (ECMO) showed no clear difference in all‐cause mortality: VA ECMO subgroup compared with conventional care (low certainty).

1 finding from 1 review

Summary of findings table ‐ Extracorporeal membrane oxygenation (ECMO) vs usual care

All‐cause mortality at 6 months (subgroup) · severe cardiorespiratory failure and cardiac arrest

Summary of findings table ‐ Extracorporeal membrane oxygenation (ECMO) showed no clear difference in all‐cause mortality: ECPR subgroup compared with conventional care (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Extracorporeal membrane oxygenation (ECMO) vs usual care

Major hemorrhage · severe cardiorespiratory failure and cardiac arrest

Summary of findings table ‐ Extracorporeal membrane oxygenation (ECMO) probably leads to higher major hemorrhage: all available studies compared with conventional care (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Extracorporeal membrane oxygenation (ECMO) vs usual care

Neurologic injury: all available studies · severe cardiorespiratory failure and cardiac arrest

Summary of findings table ‐ Extracorporeal membrane oxygenation (ECMO) showed no clear difference in neurologic injury: all available studies compared with conventional care (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse effects during treatment Intervention: Hyperbaric chamber/ 160 millibars versus supplementary oxygen · people suffering from high altitude illness
1 finding from 1 review

Early intervention (mobilization or active exercise) vs usual care

Adverse events Proportion of participants with one or more events, or proportion of intervention sessions where an event occurred (falls, accidental dislodgement of attachments, haemodynamic instability, oxygen desaturation or any other adverse ev... · critically ill, mechanically ventilated adults
1 finding from 1 review