Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

77 questions · 78 findings · 13 reviews · Neonatal · Headline outcomes only

No studies found 26 · 33.3%GRADE not reported 2 · 2.6%Very low 15 · 19.2%Low 16 · 20.5%Moderate 17 · 21.8%High 2 · 2.6%

Dextrose gel vs control

Correction of hypoglycaemia for each hypoglycaemic event before discharge home (investigator defined) · newborn infants with hypoglycaemia

Oral dextrose gel showed no clear difference in correction of hypoglycaemia for each hypoglycaemic event before… compared with control (moderate certainty).

1 finding from 1 review

Dextrose gel vs control

Major neurological disability at 2 years of age (Defined as any of the following: legal blindness, sensorineural deafness requiring hearing aids, moderate or severe cerebral palsy or developmental delay/intellectual impairment (developmental quoti... · newborn infants with hypoglycaemia

Oral dextrose gel showed no clear difference in major neurological disability at age 2 years or olderb Defined as… compared with control (low certainty).

1 finding from 1 review

Dextrose gel vs control

Receipt of intravenous treatment for hypoglycaemia (yes/no) · newborn infants with hypoglycaemia

It is very uncertain whether oral dextrose gel changes receipt of intravenous treatment for hypoglycaemia before discharge… compared with control (very low certainty).

1 finding from 1 review

Dextrose gel vs control

Breastfeeding (exclusive after discharge) ‐ not reported (WHO 2008 definition (yes/no)) · newborn infants with hypoglycaemia

Oral dextrose gel probably leads to higher exclusive breastfeeding after discharge (WHO 2008 definition (yes/no)) compared with control (moderate certainty).

1 finding from 1 review

Paracetamol plus ibuprofen (oral or IV) vs ibuprofen plus placebo (oral or IV) or no intervention

Failure of PDA closure after first course of treatment (assessed by post‐treatment ECHO) · preterm or low birth weight infants with PDA

Paracetamol plus ibuprofen (oral or IV) showed no clear difference in failure of PDA closure after first course of treatment (assessed by… compared with ibuprofen plus placebo (oral or IV) or no intervention (low certainty).

1 finding from 1 review

Paracetamol plus ibuprofen (oral or IV) vs ibuprofen plus placebo (oral or IV) or no intervention

Necrotizing enterocolitis during initial hospital stay (by radiological diagnosis) · preterm or low birth weight infants with PDA

Paracetamol plus ibuprofen (oral or IV) showed no clear difference in necrotizing enterocolitis during initial hospital stay (radiological… compared with ibuprofen plus placebo (oral or IV) or no intervention (low certainty).

1 finding from 1 review

Summary of findings table for oral immunoglobulin vs control

Definite necrotizing enterocolitis (NEC) during study period · preventing necrotizing enterocolitis in preterm and low birth weight neonates

Summary of findings table for oral immunoglobulin showed no clear difference in definite necrotizing enterocolitis (NEC) during study period compared with control (low certainty).

1 finding from 1 review

Summary of findings table for oral immunoglobulin vs control

Definite necrotizing enterocolitis (NEC) during study period ‐ IgA/IgG · preventing necrotizing enterocolitis in preterm and low birth weight neonates

It is very uncertain whether summary of findings table for oral immunoglobulin changes definite necrotizing enterocolitis (NEC) during study period ‐ IgA/IgG compared with control (very low certainty).

1 finding from 1 review

Summary of findings table for oral immunoglobulin vs control

Definite necrotizing enterocolitis (NEC) during study period ‐ IgG · preventing necrotizing enterocolitis in preterm and low birth weight neonates

Summary of findings table for oral immunoglobulin showed no clear difference in definite necrotizing enterocolitis (NEC) during study period ‐ IgG compared with control (low certainty).

1 finding from 1 review