Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

31 questions · 31 findings · 4 reviews · Anaesthesia

No studies found 1 · 3.2%GRADE not reported 4 · 12.9%Very low 15 · 48.4%Low 7 · 22.6%Moderate 4 · 12.9%High 0 · 0%

Supplemental IV crystalloid vs control IV crystalloid volume

Nausea · participants aged 6 months or older undergoing surgical procedures under general anaesthesia

Supplemental IV crystalloid probably leads to lower risk of PON, defined as the presence of subjective nausea, reported… compared with control IV crystalloid volume (moderate certainty).

1 finding from 1 review

Supplemental IV crystalloid vs control IV crystalloid volume

Risk of POV, reported dichotomously by any discrete episodes of vomiting · participants aged 6 months or older undergoing surgical procedures under general anaesthesia

Supplemental IV crystalloid probably leads to lower risk of POV, reported dichotomously by any discrete episodes of… compared with control IV crystalloid volume (moderate certainty).

1 finding from 1 review

Supplemental IV crystalloid vs control IV crystalloid volume

Risk of requiring pharmacologic treatment for PONV, reported dichotomously as the use of any medication intended to treat nausea or vomiting during the postoperative period · participants aged 6 months or older undergoing surgical procedures under general anaesthesia

Supplemental IV crystalloid probably leads to lower risk of requiring pharmacologic treatment for PONV, reported… compared with control IV crystalloid volume (moderate certainty).

1 finding from 1 review

Supplemental IV crystalloid vs control IV crystalloid volume

Risk of unintended postoperative admission to hospital, reported dichotomously as admission to an inpatient unit of a participant after an intended ambulatory surgical procedure · participants aged 6 months or older undergoing surgical procedures under general anaesthesia

Supplemental IV crystalloid showed no clear difference in risk of unintended postoperative admission to hospital, reported… compared with control IV crystalloid volume (low certainty).

1 finding from 1 review

Supplemental IV crystalloid vs control IV crystalloid volume

Risk of suffering a serious adverse event, reported dichotomously as the occurrence of any of: admission to high‐dependency unit, postoperative cardiac or respiratory complication, or death · participants aged 6 months or older undergoing surgical procedures under general anaesthesia

The review found no eligible studies for this question.

1 finding from 1 review

Epidural analgesia vs systemic analgesia

Vomiting · children having undergone thoraco‐lumbar spine surgery. 3 trials included in the analysis contained participants older than 18 years:…

Epidural analgesia showed no clear difference in vomiting up to 48 hours after surgery compared with systemic analgesia (low certainty).

1 finding from 1 review

Epidural analgesia vs systemic analgesia

Return of gastrointestinal function · children having undergone thoraco‐lumbar spine surgery. 3 trials included in the analysis contained participants older than 18 years:…

It is very uncertain whether epidural analgesia changes return of gastrointestinal function compared with systemic analgesia (very low certainty).

1 finding from 1 review

Epidural analgesia vs systemic analgesia

Complications · children having undergone thoraco‐lumbar spine surgery. 3 trials included in the analysis contained participants older than 18 years:…

It is very uncertain whether epidural analgesia changes complications compared with systemic analgesia (very low certainty).

1 finding from 1 review

ProSeal vs Classic laryngeal mask airway (LMA)

Inadequate oxygenation (SaO₂ < 90% on peripheral oxygen saturation) · adult patients (18 years of age and older) for positive pressure ventilation undergoing elective surgery

It is very uncertain whether proSeal changes inadequate oxygenation (SaO₂ < 90% on peripheral oxygen saturation) compared with classic laryngeal mask airway (LMA) (very low certainty).

1 finding from 1 review

ProSeal vs Classic laryngeal mask airway (LMA)

Sore throat · adult patients (18 years of age and older) for positive pressure ventilation undergoing elective surgery

ProSeal showed no clear difference in sore throat compared with classic laryngeal mask airway (LMA) (low certainty).

1 finding from 1 review

ProSeal vs Classic laryngeal mask airway (LMA)

Regurgitation · adult patients (18 years of age and older) for positive pressure ventilation undergoing elective surgery

ProSeal showed no clear difference in regurgitation compared with classic laryngeal mask airway (LMA) (low certainty).

1 finding from 1 review

Nitroglycerin vs no treatment

All‐cause mortality in 30 days post operation · patients (15 years of age and older) undergoing non‐cardiac surgery under any type of anaesthesia

It is very uncertain whether nitroglycerin changes all‐cause mortality in 30 days post operation compared with no treatment (very low certainty).

1 finding from 1 review