Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

53 questions · 53 findings · 10 reviews · Hepato-Biliary

No studies found 10 · 18.9%GRADE not reported 2 · 3.8%Very low 18 · 34%Low 11 · 20.8%Moderate 1 · 1.9%High 11 · 20.8%

TACE followed by 3‐DCRT vs chemoembolisation

Proportion of participants without tumour response (CR+PR) · primary hepatocellular carcinoma

TACE followed by 3‐DCRT may leads to lower proportion of participants without tumour response (CR+PR) compared with TACE (low certainty).

1 finding from 1 review

TACE followed by 3‐DCRT vs chemoembolisation

Non‐serious adverse events: leukopenia · primary hepatocellular carcinoma

It is very uncertain whether TACE followed by 3‐DCRT changes non‐serious adverse events: leukopenia compared with TACE (very low certainty).

1 finding from 1 review

TACE followed by 3‐DCRT vs chemoembolisation

Non‐serious adverse events: serum transaminases elevation · primary hepatocellular carcinoma

It is very uncertain whether TACE followed by 3‐DCRT changes non‐serious adverse events: serum transaminases elevation compared with TACE (very low certainty).

1 finding from 1 review

TACE followed by 3‐DCRT vs chemoembolisation

Non‐serious adverse events: total bilirubin elevation · primary hepatocellular carcinoma

It is very uncertain whether TACE followed by 3‐DCRT changes non‐serious adverse events: total bilirubin elevation compared with TACE (very low certainty).

1 finding from 1 review

TACE followed by 3‐DCRT vs chemoembolisation

Proportion of participants without serum AFP normalisation · primary hepatocellular carcinoma

It is very uncertain whether TACE followed by 3‐DCRT changes proportion of participants without serum AFP normalisation compared with TACE (very low certainty).

1 finding from 1 review

Hypothermic oxygenated perfusion (HOPE) vs static cold storage (SCS)

Ischaemic biliary complications (donated following brain death (DBD)) · liver transplant recipients

Hypothermic oxygenated perfusion (HOPE) showed no clear difference in ischaemic biliary complications (donated following brain death (DBD)) compared with static cold storage (SCS); GRADE not reported.

1 finding from 1 review

Hypothermic oxygenated perfusion (HOPE) vs static cold storage (SCS)

Ischaemic biliary complications (donated following circulatory death (DCD)) · liver transplant recipients

Hypothermic oxygenated perfusion (HOPE) led to lower ischaemic biliary complications (donated following circulatory death… compared with static cold storage (SCS); GRADE not reported.

1 finding from 1 review

Intervention not reported

Participants with any complication: up to 3 months following randomisation · participants with alcoholic hepatitis at high risk of mortality and morbidity

It is very uncertain whether the intervention changes participants with any complication: up to 3 months following… (very low certainty).

1 finding from 1 review

Intervention not reported

There was no evidence of differences in the proportion of participants experiencing serious adverse events (for any of the comparisons Quality of evidence = very low1,2,3. · people undergoing liver resection
1 finding from 1 review

Intervention not reported

There was no evidence of differences in the number of serious adverse events for any of the comparisons Quality of evidence = very low1,2,3. · people undergoing liver resection

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Number requiring allogeneic blood transfusion ‐ Low central venous pressure (CVP) versus control. · patients with liver resection.

It is very uncertain whether the intervention changes number requiring allogeneic blood transfusion ‐ Low central venous… (very low certainty).

1 finding from 1 review