Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

339 questions · 355 findings · 25 reviews

No studies found 134 · 37.7%GRADE not reported 38 · 10.7%Very low 87 · 24.5%Low 66 · 18.6%Moderate 27 · 7.6%High 3 · 0.8%

Primary outcome: topical local anaesthetics vs infiltrated local anaesthetics or other topical agents

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · adults and paediatric patients with dermal laceration
5 findings from 1 review
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Primary outcome: topical local anaesthetics vs infiltrated local anaesthetics or other topical agents

Anaesthetic‐related adverse effects · adults and paediatric patients with dermal laceration

Primary outcome: topical local anaesthetics led to lower anaesthetic‐related adverse effects compared with infiltrated local anaesthetics or other topical agents; GRADE not reported.

1 finding from 1 review

Infiltration injection local anaesthetic vs no local anaesthetic wound infiltration

Serious adverse events · patients with people undergoing laparoscopic cholecystectomy.

It is very uncertain whether local anaesthetic wound infiltration changes serious adverse events compared with no local anaesthetic wound infiltration (very low certainty).

1 finding from 1 review

Infiltration injection local anaesthetic vs no local anaesthetic wound infiltration

Proportion discharged as day surgery · patients with people undergoing laparoscopic cholecystectomy.

It is very uncertain whether local anaesthetic wound infiltration changes proportion discharged as day surgery compared with no local anaesthetic wound infiltration (very low certainty).

1 finding from 1 review

Summary of findings: corticosteroid and local anaesthetic injection (CS+LA) vs local anaesthetic injection (LA)

Satisfaction: 4‐item Likert scale (dichotomised into satisfied and dissatisfied) · Morton's neuroma

Summary of findings: corticosteroid and local anaesthetic injection… showed no clear difference in satisfaction: Modified Johnson Scale (dichotomised into satisfied… compared with local anaesthetic injection (LA) (low certainty).

1 finding from 1 review