Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

30 questions · 30 findings · 9 reviews · Stroke

No studies found 5 · 16.7%GRADE not reported 0 · 0%Very low 14 · 46.7%Low 5 · 16.7%Moderate 5 · 16.7%High 1 · 3.3%

Endovascular therapy plus conventional medical treatment vs conventional medical treatment alone

Long‐term ipsilateral stroke · people with symptomatic intracranial artery stenosis

Endovascular therapy plus conventional medical treatment probably leads to higher ipsilateral stroke compared with conventional medical treatment alone (moderate certainty).

1 finding from 1 review

Main comparison of patch angioplasty vs primary closure

Stroke · patients undergoing carotid endarterectomy, whether the initial indication for endarterectomy was symptomatic or asymptomatic carotid…

It is very uncertain whether main comparison of patch angioplasty changes any stroke (fatal or non‐fatal; contralateral, ipsilateral or… compared with primary closure (very low certainty).

1 finding from 1 review

Main comparison of patch angioplasty vs primary closure

Perioperative ipsilateral stroke (< 30 days) · patients undergoing carotid endarterectomy, whether the initial indication for endarterectomy was symptomatic or asymptomatic carotid…

It is very uncertain whether main comparison of patch angioplasty changes ipsilateral stroke (fatal or non‐fatal; haemorrhage or infarct)… compared with primary closure (very low certainty).

1 finding from 1 review

Main comparison of patch angioplasty vs primary closure

Long‐term any stroke · patients undergoing carotid endarterectomy, whether the initial indication for endarterectomy was symptomatic or asymptomatic carotid…

It is very uncertain whether main comparison of patch angioplasty changes any stroke (fatal or non‐fatal; contralateral, ipsilateral or… compared with primary closure (very low certainty).

1 finding from 1 review

Main comparison of patch angioplasty vs primary closure

Long‐term ipsilateral stroke · patients undergoing carotid endarterectomy, whether the initial indication for endarterectomy was symptomatic or asymptomatic carotid…

It is very uncertain whether main comparison of patch angioplasty changes ipsilateral stroke (fatal or non‐fatal; haemorrhage or infarct)… compared with primary closure (very low certainty).

1 finding from 1 review

Carotid artery stenting vs endarterectomy

Death or any stroke between randomisation and 30 days after treatment or ipsilateral stroke until end of · people with symptomatic carotid stenosis

Carotid artery stenting leads to higher death or any stroke between randomisation and 30 days after… compared with endarterectomy (high certainty).

1 finding from 1 review

Carotid artery stenting vs endarterectomy

Death or any stroke between randomisation and 30 days after treatment or ipsilateral stroke until end of · asymptomatic carotid stenosis

Carotid artery stenting showed no clear difference in death or any stroke between randomisation and 30 days after… compared with endarterectomy (moderate certainty).

1 finding from 1 review

Intervention not reported

Ipsilateral ischaemic stroke, and any operative stroke or death (five‐year cumulative) · people with carotid stenosis and recent transient ischaemic attacks (TIA) or minor ischaemic strokes in the territory of that artery

The intervention showed no clear difference in ipsilateral ischaemic stroke, and any operative stroke or death… (moderate certainty).

1 finding from 1 review

Intervention not reported

Disabling or fatal ipsilateral ischaemic or operative stroke and death (five‐year cumulative) · people with carotid stenosis and recent transient ischaemic attacks (TIA) or minor ischaemic strokes in the territory of that artery

The intervention showed no clear difference in disabling or fatal ipsilateral ischaemic or operative stroke and… (moderate certainty).

1 finding from 1 review