Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,018 questions · 3,100 findings · 369 reviews · Headline outcomes only

No studies found 774 · 25%GRADE not reported 108 · 3.5%Very low 727 · 23.5%Low 840 · 27.1%Moderate 474 · 15.3%High 177 · 5.7%

Sinonasal debridement vs no debridement

Postoperative endoscopic appearance of the sinonasal surgical cavities: Lund‐Kennedy endoscopic score (range 1 to 10) · adult patients who underwent primary endoscopic sinus surgery, with a diagnosis of recurrent acute or chronic rhinosinusitis

Sinonasal debridement showed no clear difference in postoperative endoscopic appearance of the sinonasal surgical… compared with no debridement (low certainty).

1 finding from 1 review

Fibrinolytics vs placebo

Overall treatment failure, including mortality, thoracic surgery or referral for further fibrinolytic therapy · adult parapneumonic effusions and empyema

It is very uncertain whether fibrinolytics changes overall treatment failure, including mortality, thoracic surgery or… compared with placebo (very low certainty).

1 finding from 1 review

Aminophylline vs placebo

Survival to hospital discharge · participants with bradyasystolic cardiac arrest in adults

Aminophylline showed no clear difference in survival to hospital discharge compared with placebo (moderate certainty).

2 findings from 1 review

Aminophylline vs placebo

Return of spontaneous circulation · participants with bradyasystolic cardiac arrest in adults

Aminophylline showed no clear difference in return of spontaneous circulation compared with placebo (high certainty).

2 findings from 1 review

Aminophylline vs placebo

Early administration of aminophylline: survival to hospital admission · participants with bradyasystolic cardiac arrest in adults

Aminophylline showed no clear difference in survival to admission compared with placebo (moderate certainty).

2 findings from 1 review

Quinolone vs macrolides

Quality of life Drug resistance/microbial sensitivity Serious adverse events Lung function Hospitalisations Adverse events/side effects Number of participants colonised with P aeruginosa · patients with chronic obstructive pulmonary disease

The review found no eligible studies for this question.

1 finding from 1 review

Quinolone vs tetracycline

Quality of life Drug resistance/microbial sensitivity Serious adverse events Lung function Hospitalisations Adverse events/side effects Number of participants colonised with P aeruginosa · patients with chronic obstructive pulmonary disease

The review found no eligible studies for this question.

1 finding from 1 review