Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

185 questions · 194 findings · 16 reviews · Urology

No studies found 40 · 20.6%GRADE not reported 15 · 7.7%Very low 29 · 14.9%Low 71 · 36.6%Moderate 35 · 18%High 4 · 2.1%

Potassium paraaminobenzoate vs placebo

Patient‐reported ability to have intercourse · men with acute (maximum of 12 months) Peyronie's disease with no prior treatment and no evidence of calcified plaques (pain during…

Potassium paraaminobenzoate showed no clear difference in patient‐reported ability to have intercourse compared with placebo (low certainty).

1 finding from 1 review

Potassium paraaminobenzoate vs placebo

Treatment‐related adverse effects · men with acute (maximum of 12 months) Peyronie's disease with no prior treatment and no evidence of calcified plaques (pain during…

It is very uncertain whether potassium paraaminobenzoate changes treatment‐related adverse effects compared with placebo (very low certainty).

1 finding from 1 review

Potassium paraaminobenzoate vs placebo

Treatment discontinuation · men with acute (maximum of 12 months) Peyronie's disease with no prior treatment and no evidence of calcified plaques (pain during…

It is very uncertain whether potassium paraaminobenzoate changes discontinuation from treatment compared with placebo (very low certainty).

1 finding from 1 review

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs placebo or usual care

Minor surgical complications · Percutaneous nephrolithotomy

Topical TXA may leads to lower minor surgical complications compared with no TXA (placebo or usual care) (low certainty).

1 finding from 1 review