Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

203 questions · 208 findings · 26 reviews · Neonatal · Headline outcomes only

No studies found 3 · 1.4%GRADE not reported 23 · 11.1%Very low 59 · 28.4%Low 107 · 51.4%Moderate 12 · 5.8%High 4 · 1.9%

Late parenteral nutrition vs early parenteral nutrition

Healthcare‐associated blood stream infection · critically ill term and late preterm infants

Late parenteral nutrition showed no clear difference in healthcare‐associated blood stream infection compared with early parenteral nutrition (low certainty).

1 finding from 1 review

Fish oil lipid emulsion (LE) vs S‐LE

Parenteral nutrition‐associated liver disease/cholestasis · Parenterally fed preterm infants

All fish oil containing LE showed no clear difference in parenteral nutrition‐associated liver disease/cholestasis compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsion (LE) vs S‐LE

Parenteral nutrition‐associated liver disease/cholestasis · Parenterally fed preterm infants

All alternative LE showed no clear difference in parenteral nutrition‐associated liver disease/cholestasis compared with S‐LE (low certainty).

1 finding from 1 review

Enteral zinc supplementation vs no zinc supplementation

All‐cause mortality (between start of intervention and end of · preterm infants

Enteral zinc supplementation may leads to lower all‐cause mortality (between start of intervention and end of compared with no zinc supplementation (low certainty).

1 finding from 1 review