Cochrane · systematic review · CD012797
Enteral zinc supplementation for prevention of morbidity and mortality in preterm neonates
Staub, E, Evers, K, Askie, LM · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
5
No studies
1
Included studies
NR
No studies 1 · 14.3%Ungraded 1 · 14.3%Very low 0 · 0%Low 4 · 57.1%Moderate 1 · 14.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Enteral zinc supplementation compared to no zinc supplementation for prevention of morbidity and mortality in preterm neonates
Population: preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality (between start of intervention and end of Enteral zinc supplementation vs no zinc supplementation | RR 0.55 [0.31, 0.97] | 3 studies · 345 participants | Low |
Neurodevelopmental disability at 18 to 24 months Enteral zinc supplementation vs no zinc supplementation | no estimate extracted | 0 participants | Ungraded |
Bronchopulmonary dysplasia Enteral zinc supplementation vs no zinc supplementation | RR 0.66 [0.31, 1.4] | 1 study · 193 participants | Low |
Retinopathy of prematurity Enteral zinc supplementation vs no zinc supplementation | RR 0.14 [0.01, 2.7] | 1 study · 193 participants | Low |
Bacterial sepsis Enteral zinc supplementation vs no zinc supplementation | RR 1.11 [0.6, 2.04] | 2 studies · 293 participants | Moderate |
Necrotising enterocolitis Enteral zinc supplementation vs no zinc supplementation | RR 0.08 [0, 1.33] | 1 study · 193 participants | Low |
Change in growth (between start and end of intervention, between 6 weeks to 6 months) Enteral zinc supplementation vs no zinc supplementation | no estimate extracted | NR | No studies |