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What do systematic reviews say?

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Evidence found and GRADE certainty

24 questions · 29 findings · 4 reviews · Cystic Fibrosis and Genetic Disorders · Headline outcomes only

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No studies found 21 · 72.4%GRADE not reported 1 · 3.4%Very low 0 · 0%Low 5 · 17.2%Moderate 2 · 6.9%High 0 · 0%

Summary of findings for combination antimicrobial susceptibility testing vs conventional treatment (separate testing)

Lung function(FEV1 or FVC L/min or % predicted) · adults and children with pulmonary exacerbation due to Pseudomonas aeruginosa

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings for combination antimicrobial susceptibility testing vs conventional treatment (separate testing)

Length of hospital stay · adults and children with pulmonary exacerbation due to Pseudomonas aeruginosa

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings for combination antimicrobial susceptibility testing vs conventional treatment (separate testing)

Sputum bacterial density (CFU/mL) · adults and children with pulmonary exacerbation due to Pseudomonas aeruginosa

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings for combination antimicrobial susceptibility testing vs conventional treatment (separate testing)

All‐cause mortality · adults and children with pulmonary exacerbation due to Pseudomonas aeruginosa

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings: oral antioxidant combination vs control

FEV1 % predicted: absolute change from baseline · children with cystic fibrosis

The review found no eligible studies for this question.

2 findings from 1 review

Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy

Change in FEV1 % predicted at end of antibiotic course: absolute post‐treatment values · adults and children with cystic fibrosis

Summary of findings: single showed no clear difference in change in FEV1 % predicted at end of antibiotic course: absolute… compared with combination intravenous anti‐pseudomonal antibiotic therapy (low certainty).

1 finding from 1 review

Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy

Time to next course of antibiotics  · adults and children with cystic fibrosis

The review found no eligible studies for this question.

2 findings from 1 review

Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy

Adverse events during treatment · adults and children with cystic fibrosis

The review found no eligible studies for this question.

2 findings from 1 review

Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy

Change in sputum P aeruginosa density at end of treatment (cfu/g) · adults and children with cystic fibrosis

Summary of findings: single showed no clear difference in change in sputum P aeruginosa density at end of treatment (cfu/g) compared with combination intravenous anti‐pseudomonal antibiotic therapy (moderate certainty).

2 findings from 1 review

Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy

Need for extra treatment · adults and children with cystic fibrosis

The review found no eligible studies for this question.

2 findings from 1 review