Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

53 questions · 55 findings · 8 reviews · Headline outcomes only

No studies found 12 · 21.8%GRADE not reported 0 · 0%Very low 8 · 14.5%Low 21 · 38.2%Moderate 14 · 25.5%High 0 · 0%

Topical clindamycin vs placebo

Adverse effects (non‐serious) · participants with hidradenitis suppurativa

Topical clindamycin showed no clear difference in adverse effects (non‐serious) compared with placebo (moderate certainty).

1 finding from 1 review

Clindamycin plus aminoglycoside vs other regimens

Severe complication ‐ lincosamides versus cephalosporins · women with postpartum endometritis

It is very uncertain whether clindamycin plus aminoglycoside changes severe complication ‐ lincosamides versus cephalosporins compared with any other regimen (very low certainty).

1 finding from 1 review

Clindamycin plus aminoglycoside vs other regimens

Wound infection · women with postpartum endometritis

Clindamycin plus aminoglycoside may leads to lower wound infection ‐ lincosamides versus cephalosporins compared with any other regimen (low certainty).

2 findings from 1 review

Clindamycin plus aminoglycoside vs other regimens

Allergic reaction · women with postpartum endometritis

Clindamycin plus aminoglycoside showed no clear difference in allergic reaction ‐ lincosamides versus cephalosporins compared with any other regimen (low certainty).

2 findings from 1 review

Clindamycin phosphate 1.2% + tretinoin 0.025% gel vs placebo

Proportion of participants with adverse event · Participants with rosacea

Clindamycin phosphate 1.2% + tretinoin 0.025% gel probably leads to higher proportion of participants with adverse event compared with placebo (moderate certainty).

1 finding from 1 review

Clindamycin phosphate 1.2% + tretinoin 0.025% gel vs placebo

Assessment of erythema or telangiectasia · Participants with rosacea

Clindamycin phosphate 1.2% + tretinoin 0.025% gel showed no clear difference in assessment of erythema or telangiectasia compared with placebo (moderate certainty).

1 finding from 1 review