Cochrane · systematic review · CD010485
Interventions for treating genital Chlamydia trachomatis infection in pregnancy
Cluver, C, Novikova, N, Eriksson, DOA, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 25%Low 2 · 25%Moderate 3 · 37.5%High 1 · 12.5%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Erythromycin compared to placebo for treating genital Chlamydia trachomatis infection in pregnancy
Population: Pregnant women with a confirmed Chlamydia trachomatis infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Microbiological cure Erythromycin vs placebo | RR 2.64 [1.6, 4.38] | 2 studies · 495 participants | Moderate Downgraded: inconsistency |
Clindamycin compared to placebo for treating genital Chlamydia trachomatis infection in pregnancy
Population: Pregnant women with a confirmed Chlamydia trachomatis infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Microbiological cure Clindamycin vs placebo | RR 4.08 [2.35, 7.08] | 1 study · 85 participants | Low |
Amoxicillin compared to placebo for treating genital Chlamydia trachomatis infection in pregnancy
Population: Pregnant women with a confirmed Chlamydia trachomatis infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Microbiological cure Amoxicillin vs placebo | RR 2 [0.59, 6.79] | 1 study · 15 participants | Very low |
Amoxicillin compared to azithromycin for treating genital Chlamydia trachomatis infection in pregnancy
Population: Pregnant women with a confirmed Chlamydia trachomatis infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Microbiological cure Amoxicillin vs azithromycin | RR 0.89 [0.71, 1.12] | 2 studies · 144 participants | Very low Downgraded: imprecision |
Amoxicillin compared to erythromycin for treating genital Chlamydia trachomatis infection in pregnancy
Population: Pregnant women with a confirmed Chlamydia trachomatis infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Microbiological cure Amoxicillin vs erythromycin | RR 0.97 [0.93, 1.01] | 4 studies · 466 participants | High |
Azithromycin compared to erythromycin for treating genital Chlamydia trachomatis infection in pregnancy
Population: Pregnant women with a confirmed Chlamydia trachomatis infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Microbiological cure Azithromycin vs erythromycin | RR 1.11 [1, 1.23] | 6 studies · 374 participants | Moderate |
Clindamycin compared to erythromycin for treating genital Chlamydia trachomatis infection in pregnancy
Population: Pregnant women with a confirmed Chlamydia trachomatis infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Microbiological cure Clindamycin vs erythromycin | RR 1.06 [0.97, 1.15] | 2 studies · 173 participants | Low Downgraded: imprecision |
Amoxicillin compared to clindamycin for treating genital Chlamydia trachomatis infection in pregnancy
Population: Pregnant women with a confirmed Chlamydia trachomatis infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Microbiological cure Amoxicillin vs clindamycin | RR 0.96 [0.89, 1.04] | 1 study · 101 participants | Moderate Downgraded: imprecision |