Question · asked by 1 review
Clindamycin phosphate 1.2% + tretinoin 0.025% gel vs placebo: Proportion of participants with adverse event
- Population
- Participants with rosacea
- Intervention
- Clindamycin phosphate 1.2% + tretinoin 0.025% gel
- Comparison
- placebo
- Outcome
- Proportion of participants with adverse event
Clindamycin phosphate 1.2% + tretinoin 0.025% gel probably leads to higher proportion of participants with adverse event compared with placebo (moderate certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Clindamycin phosphate 1.2% + tretinoin 0.025% gel vs placebo Proportion of participants with adverse event · Participants with rosacea Clindamycin phosphate 1.2% + tretinoin 0.025% gel probably leads to higher proportion of participants with adverse event compared with placebo (moderate certainty). Interventions for rosacea (2015) · Cochrane Headline outcomes only | RR 2.45 [1.42, 4.23] | 1 study · 83 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for rosacea 2015 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.