Cochrane · systematic review · CD011528
Antibiotics for treating septic abortion
Udoh, A, Effa, EE, Oduwole, O, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Fertility RegulationAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
14
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 28.6%Moderate 10 · 71.4%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Clindamycin versus penicillin plus chloramphenicol compared to for
Population: patients with septic abortion
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Fever index (mean degree‐hour) ‐ all women Clindamycin vs penicillin plus chloramphenicol compared to for | no estimate extracted | 1 study · 77 participants | Moderate Downgraded: risk of bias, imprecision |
Fever index (mean degree‐hour) ‐ bacteraemic patients Clindamycin vs penicillin plus chloramphenicol compared to for | no estimate extracted | 1 study · 29 participants | Moderate Downgraded: risk of bias, imprecision |
Duration of hospitalisation Clindamycin vs penicillin plus chloramphenicol compared to for | no estimate extracted | 1 study · 77 participants | Moderate Downgraded: risk of bias, imprecision |
Complications Clindamycin vs penicillin plus chloramphenicol compared to for | RR 7.57 [0.98, 58.61] | 1 study · 77 participants | Moderate Downgraded: risk of bias, imprecision |
Penicillin plus chloramphenicol versus cephalothin plus kanamycin for treating septic abortion
Population: patients with treating septic abortion
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Time to fever resolution (mean time) Penicillin plus chloramphenicol vs cephalothin plus kanamycin | no estimate extracted | 1 study · 56 participants | Low Downgraded: risk of bias, imprecision |
Absence of fever during D&C (mean time) Penicillin plus chloramphenicol vs cephalothin plus kanamycin | no estimate extracted | 1 study · 56 participants | Low Downgraded: risk of bias, imprecision |
Antibiotics after D&C versus D&C during antibiotics for treating septic abortion
Population: patients with treating septic abortion
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Absence of fever (degree‐hour) ‐ Clindamycin after D&C versus D&C during clindamycin Antibiotics after D&C vs D&C during antibiotics | no estimate extracted | 1 study · 37 participants | Moderate Downgraded: risk of bias, imprecision |
Absence of fever (degree‐hour) ‐ Penicillin + chloramphenicol after D&C versus D&C during penicillin + chloramphenicol therapy) Antibiotics after D&C vs D&C during antibiotics | no estimate extracted | 1 study · 39 participants | Moderate Downgraded: risk of bias, imprecision |
Tetracycline versus penicillin G for treating septic abortion
Population: patients with septic abortion
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Fever resolution time (days) Tetracycline vs penicillin G | no estimate extracted | 1 study · 100 participants | Low Downgraded: risk of bias |
Leukocytosis resolution time (days) Tetracycline vs penicillin G | no estimate extracted | 1 study · 100 participants | Low Downgraded: risk of bias |
Adverse events
Population: patients with septic abortion
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pelvic abscess, salpingitis, urinary tract infection | RR 4.32 [0.51, 36.95] | 1 study · 77 participants | Moderate Downgraded: imprecision |
Treatment failure | RR 5.39 [0.27, 108.8] | 1 study · 77 participants | Moderate Downgraded: imprecision |
Drug reaction | RR 3.24 [0.14, 77.06] | 1 study · 77 participants | Moderate Downgraded: imprecision |
Phlebitis | RR 0.36 [0.02, 8.56] | 1 study · 77 participants | Moderate Downgraded: imprecision |