Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

21 questions · 21 findings · 5 reviews · Wounds · Headline outcomes only

No studies found 2 · 9.5%GRADE not reported 0 · 0%Very low 10 · 47.6%Low 4 · 19%Moderate 4 · 19%High 1 · 4.8%

Chlorhexidine vs non‐antibacterial

Time to complete healing · people with burns

Chlorhexidine showed no clear difference in wound healing: time to complete healing (time‐to‐event data):… compared with non‐antibacterial (low certainty).

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    HR 0.71 [0.39, 1.29]
    1 study · 51 participants
    Low

Chlorhexidine vs non‐antibacterial

Wound healing · people with burns

Chlorhexidine may leads to higher wound healing (mean time to healing): chlorhexidine versus… compared with non‐antibacterial (low certainty).

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    MD 4.08 [0.73, 7.43]
    1 study · 51 participants
    Low

Chlorhexidine vs non‐antibacterial

Infection: chlorhexidine versus no antimicrobial/no additional antimicrobial · people with burns

It is very uncertain whether chlorhexidine changes infection: chlorhexidine versus no antimicrobial/no additional… compared with non‐antibacterial (very low certainty).

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    RR 1.11 [0.54, 2.27]
    2 studies · 172 participants
    Very low

Chlorhexidine vs non‐antibacterial

Adverse events: chlorhexidine versus hydrocolloid · people with burns

It is very uncertain whether chlorhexidine changes adverse events: chlorhexidine versus hydrocolloid compared with non‐antibacterial (very low certainty).

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    RR 0.2 [0.02, 1.65]
    1 study · 98 participants
    Very low

Chlorhexidine vs povidone‐iodine

Catheter‐related BSI ‐ overall comparison between chlorhexidine and povidone‐iodine (during in‐patient stay) · patients with a central venous catheter

It is very uncertain whether chlorhexidine changes catheter‐related BSI ‐ overall comparison between chlorhexidine and… compared with povidone‐iodine (very low certainty).

1 finding from 1 review

Chlorhexidine vs povidone‐iodine

Catheter‐related BSI ‐ subgroup: chlorhexidine in aqueous solution versus povidone‐iodine in aqueous solution · patients with a central venous catheter

It is very uncertain whether chlorhexidine changes catheter‐related BSI ‐ subgroup: chlorhexidine in aqueous solution… compared with povidone‐iodine (very low certainty).

1 finding from 1 review

Chlorhexidine vs povidone‐iodine

Catheter‐related BSI ‐ subgroup: chlorhexidine in alcohol versus povidone‐iodine in aqueous solution · patients with a central venous catheter

It is very uncertain whether chlorhexidine changes catheter‐related BSI ‐ subgroup: chlorhexidine in alcohol versus… compared with povidone‐iodine (very low certainty).

1 finding from 1 review

Chlorhexidine vs povidone‐iodine

Catheter‐related BSI ‐ subgroup: chlorhexidine in alcohol versus povidone‐iodine in alcohol · patients with a central venous catheter

Chlorhexidine showed no clear difference in catheter‐related BSI ‐ subgroup: chlorhexidine in alcohol versus… compared with povidone‐iodine (moderate certainty).

1 finding from 1 review

Chlorhexidine vs povidone‐iodine

All‐cause mortality ‐ Chlorhexidine in aqueous solution versus povidone‐iodine in aqueous solution Clinical assessment · patients with a central venous catheter

Chlorhexidine showed no clear difference in all‐cause mortality ‐ Chlorhexidine in aqueous solution versus… compared with povidone‐iodine (low certainty).

1 finding from 1 review

Chlorhexidine vs povidone‐iodine

All‐cause mortality ‐ Chlorhexidine in alcohol versus povidone‐iodine in aqueous solution Clinical assessment · patients with a central venous catheter

Chlorhexidine showed no clear difference in all‐cause mortality ‐ Chlorhexidine in alcohol versus… compared with povidone‐iodine (low certainty).

1 finding from 1 review

Bathing of the critically ill with chlorhexidine vs bathing with soap and water or non‐antimicrobial washcloths

Mortality (ICU, hospital) (days) · critically ill patients

It is very uncertain whether bathing of the critically ill with chlorhexidine changes mortality Data collected (where reported) in hospital, in the ICU,… compared with bathing with soap and water or non‐antimicrobial washcloths (very low certainty).

1 finding from 1 review