Cochrane · systematic review · CD010140
Skin antisepsis for reducing central venous catheter‐related infections
Lai, NM, Lai, NA, O'Riordan, E, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
WoundsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
6
No studies
2
Included studies
NR
No studies 2 · 25%Ungraded 0 · 0%Very low 3 · 37.5%Low 2 · 25%Moderate 1 · 12.5%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Chlorhexidine compared to povidone‐iodine in reducing catheter related infections
Population: patients with a central venous catheter
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Catheter‐related BSI ‐ overall comparison between chlorhexidine and povidone‐iodine (during in‐patient stay) Chlorhexidine vs povidone‐iodine | RR 0.64 [0.41, 0.99] | 4 studies · 1436 participants | Very low Downgraded: risk of bias |
Catheter‐related BSI ‐ subgroup: chlorhexidine in aqueous solution versus povidone‐iodine in aqueous solution Chlorhexidine vs povidone‐iodine | RR 0.64 [0.32, 1.28] | 2 studies · 452 participants | Very low Downgraded: risk of bias, imprecision |
Catheter‐related BSI ‐ subgroup: chlorhexidine in alcohol versus povidone‐iodine in aqueous solution Chlorhexidine vs povidone‐iodine | RR 0.77 [0.39, 1.53] | 2 studies · 503 participants | Very low Downgraded: risk of bias, imprecision |
Catheter‐related BSI ‐ subgroup: chlorhexidine in alcohol versus povidone‐iodine in alcohol Chlorhexidine vs povidone‐iodine | RR 0.4 [0.13, 1.24] | 1 study · 481 participants | Moderate |
Primary BSI or clinical sepsis Chlorhexidine vs povidone‐iodine | no estimate extracted | NR | No studies |
All‐cause mortality ‐ Chlorhexidine in aqueous solution versus povidone‐iodine in aqueous solution Clinical assessment Chlorhexidine vs povidone‐iodine | RR 1.15 [0.72, 1.83] | 1 study · 213 participants | Low Downgraded: risk of bias, imprecision |
All‐cause mortality ‐ Chlorhexidine in alcohol versus povidone‐iodine in aqueous solution Clinical assessment Chlorhexidine vs povidone‐iodine | RR 0.8 [0.48, 1.34] | 1 study · 222 participants | Low Downgraded: risk of bias, imprecision |
Mortality attributable the CVC‐related infections. Chlorhexidine vs povidone‐iodine | no estimate extracted | NR | No studies |